{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:05:54Z","timestamp":1777727154298,"version":"3.51.4"},"reference-count":5,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1977,1,1]],"date-time":"1977-01-01T00:00:00Z","timestamp":220924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1977,1]]},"abstract":"<jats:p>Six women with normal menstrual cycles were treated over six cycles with Fysioquens, a normophasic contraceptive consisting of 7 tablets of ethinyloestradiol (EE) 0\u00b7050 mg and 15 tablets containing 1\u00b70 mg lynestrenol +0\u00b7050 mg EE.<\/jats:p>\n                  <jats:p>In the 1st, 3rd and 6th treatment cycles and in the cycles before and after treatment, hormonal assays and other tests were carried out to determine whether ovulation had occurred.<\/jats:p>\n                  <jats:p>No treatment cycles showed any signs of ovulation, but it did occur in the pre- and post-treatment cycles. Blood pressures and liver function tests remained normal, but two of the six volunteers showed a slight increase in body-weight.<\/jats:p>","DOI":"10.1177\/030006057700500109","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T19:37:08Z","timestamp":1409859428000},"page":"53-60","source":"Crossref","is-referenced-by-count":0,"title":["The Mechanism of Action of a Normophasic Oral Contraceptive \u2018Fysioquens'"],"prefix":"10.1177","volume":"5","author":[{"given":"F","family":"Franchi","sequence":"first","affiliation":[{"name":"1a Clinica Medica Generale e Terapia della Universita di Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Luisi","sequence":"additional","affiliation":[{"name":"1a Clinica Medica Generale e Terapia della Universita di Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1977,1,1]]},"reference":[{"key":"bibr1-030006057700500109","first-page":"165","volume":"26","author":"Alicicco E","year":"1973","journal-title":"Folia Endocrinologica"},{"key":"bibr2-030006057700500109","unstructured":"Luisi M,  (1972). Atti Convegno: Metodi Radioimmunologici in Endocrinologia, Serono Symposia p. 1, 1972"},{"key":"bibr3-030006057700500109","first-page":"424","volume":"25","author":"Luisi M","year":"1972","journal-title":"Folia Endocrinologica"},{"key":"bibr4-030006057700500109","unstructured":"Luisi M, Marescotti V (1965) In: \u2018Research on Steroids: Transactions of the Second Meeting of the International Study Group for Steroid Hormones\u2019, p. 171, Rome 1965. Dec 17\u201319"},{"key":"bibr5-030006057700500109","unstructured":"Luisi M,  (1973) Lecture presented at the Annual Meeting of the Medical Society of Pisa University, May 1973"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057700500109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057700500109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:48:45Z","timestamp":1777459725000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006057700500109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,1]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,1]]}},"alternative-id":["10.1177\/030006057700500109"],"URL":"https:\/\/doi.org\/10.1177\/030006057700500109","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,1]]}}}