{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:06:10Z","timestamp":1777727170946,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1977,3,1]],"date-time":"1977-03-01T00:00:00Z","timestamp":226022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1977,3]]},"abstract":"<jats:p>The effect of tolamolol 50-300 mg three times daily in the treatment of 30 patients with mild\u2013severe hypertension was studied. The duration of therapy in the majority of cases was 3-6 months. There was a highly significant reduction of mean blood pressure (p &lt; 0\u00b7001) &lt;i&gt;for the group as a whole. Overall, 61% of patients became normotensive or showed a reduction in severity of hypertension. In the majority of cases, this improvement occurred within the first four weeks of therapy. There was no postural hypertension.<\/jats:p>\n                  <jats:p>Apart from one patient with Prurigo Besnier who developed asthma, another patient who developed severe headache and a third patient who stopped treatment without giving a reason, treatment was well tolerated and there were no other serious side or toxic effects.<\/jats:p>","DOI":"10.1177\/030006057700500205","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T18:40:06Z","timestamp":1484592006000},"page":"100-108","source":"Crossref","is-referenced-by-count":0,"title":["Tolamolol in the Treatment of Hypertension: An Open Evaluation Study"],"prefix":"10.1177","volume":"5","author":[{"given":"K","family":"Harno","sequence":"first","affiliation":[{"name":"The Municipal Health Centre of Kerava, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1977,3,1]]},"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057700500205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057700500205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:48:47Z","timestamp":1777459727000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006057700500205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,3]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1977,3]]}},"alternative-id":["10.1177\/030006057700500205"],"URL":"https:\/\/doi.org\/10.1177\/030006057700500205","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,3]]}}}