{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:07:25Z","timestamp":1777727245870,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1977,7,1]],"date-time":"1977-07-01T00:00:00Z","timestamp":236563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1977,7]]},"abstract":"<jats:p>The initial results of a study set up to investigate the gastric mucosa in rheumatic patients receiving ibuprofen are described. The study involved seven male patients, aged between 17 to 70 years, suffering from various rheumatic diseases. All patients received a daily dose of 1200 mg of ibuprofen per os divided into three fractions and taken over periods of treatment ranging from one to six weeks.<\/jats:p>\n                  <jats:p>On the data obtained by the gastric secretion test, endoscopy, and specific histological and ultrastructure studies it is concluded that, in the cases investigated, ibuprofen could not be shown to be responsible for any significant modifications of the gastric mucosa.<\/jats:p>","DOI":"10.1177\/030006057700500405","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T19:38:00Z","timestamp":1409859480000},"page":"243-252","source":"Crossref","is-referenced-by-count":8,"title":["Observations on the Gastric Mucosa of Rheumatic Patients before and after               Ibuprofen Administration as Studied by the Pentagastrin Test, Endoscopy, and Light               and Electron Microscopy"],"prefix":"10.1177","volume":"5","author":[{"given":"A Vasconcelos","family":"Teixeira","sequence":"first","affiliation":[{"name":"Department of Medicine, Divisions of Gastro-enterology and Rheumatology and               University of Oporto Centre for Experimental Morphology. Faculty of Medicine\u2014Hospital               S Jo\u00e3o, Oporto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Abrunhosa","sequence":"additional","affiliation":[{"name":"Department of Medicine, Divisions of Gastro-enterology and Rheumatology and               University of Oporto Centre for Experimental Morphology. Faculty of Medicine\u2014Hospital               S Jo\u00e3o, Oporto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Licinio","family":"Po\u00e7as","sequence":"additional","affiliation":[{"name":"Department of Medicine, Divisions of Gastro-enterology and Rheumatology and               University of Oporto Centre for Experimental Morphology. Faculty of Medicine\u2014Hospital               S Jo\u00e3o, Oporto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1977,7,1]]},"reference":[{"key":"bibr1-030006057700500405","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1973.01350160068011"},{"key":"bibr2-030006057700500405","unstructured":"Ballabio CB, Colombo B (1973) Controlled clinical evaluation of \u2018Brufen\u2019 and               indomethacin in rheumatoid arthritis, with endoscopic control. In: Abstracts                  of ibuprofen and flurbiprofen XIII International Congress of               Rheumatology, Kyoto, Japan 1973, p 12"},{"key":"bibr3-030006057700500405","doi-asserted-by":"crossref","unstructured":"Cardoe N (1970) A review of long-term experience with ibuprofen               with special reference to gastric tolerance. Rheumatology and Physical                  Medicine Suppl 28","DOI":"10.1093\/rheumatology\/X.suppl_1.28"},{"key":"bibr4-030006057700500405","doi-asserted-by":"publisher","DOI":"10.1185\/03007997509110586"},{"key":"bibr5-030006057700500405","doi-asserted-by":"publisher","DOI":"10.1007\/BF01072063"},{"key":"bibr6-030006057700500405","doi-asserted-by":"publisher","DOI":"10.1007\/BF01071955"},{"key":"bibr7-030006057700500405","first-page":"962","volume":"21","author":"Eastwood GL","year":"1973","journal-title":"Clinical Research"},{"key":"bibr8-030006057700500405","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)32927-0"},{"key":"bibr9-030006057700500405","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(75)80132-6"},{"key":"bibr10-030006057700500405","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0307-742X(21)00122-3","volume":"1","author":"Famaey JP","year":"1975","journal-title":"Clinics in Rheumatic Diseases"},{"key":"bibr11-030006057700500405","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)33594-2"},{"key":"bibr12-030006057700500405","doi-asserted-by":"publisher","DOI":"10.1007\/BF01072066"},{"key":"bibr13-030006057700500405","doi-asserted-by":"crossref","unstructured":"Lee P (1975) More recent non-steroidal                  anti-rheumatic drugs. Part II: Clinical Applications 1, 293","DOI":"10.1016\/S0307-742X(21)00122-3"},{"key":"bibr14-030006057700500405","volume":"68","author":"Mann NS","year":"1975","journal-title":"Gastroenterology"},{"key":"bibr15-030006057700500405","first-page":"913","volume":"70","author":"Mann NS","year":"1976","journal-title":"Gastroenterology"},{"key":"bibr16-030006057700500405","first-page":"143","volume":"64","author":"Mirelli E","year":"1973","journal-title":"Minerva Medicine"},{"key":"bibr17-030006057700500405","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/00365521.1974.12096858","volume":"9","author":"Myren J","year":"1974","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"bibr18-030006057700500405","doi-asserted-by":"publisher","DOI":"10.1185\/03007997509110587"},{"key":"bibr19-030006057700500405","unstructured":"Stempiem SJ, Dagradi AETD (1972) Endoscopic aspects of the gastric mucosa ten               years or more after vagotomy-pyloroplasty. In: Advances in Gastrointestinal                  Endoscopy. Ed Crespy M Marcozzy Gand Piccin Medical Books 733"},{"key":"bibr20-030006057700500405","doi-asserted-by":"crossref","unstructured":"Thompson M, Anderson M (1970) Studies of gastro-intestinal blood loss during               ibuprofen therapy. 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