{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:09:11Z","timestamp":1777727351734,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1978,3,1]],"date-time":"1978-03-01T00:00:00Z","timestamp":257558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1978,3]]},"abstract":"<jats:p>A randomized controlled trial was performed to study the efficacy of Syn-Ergel with an active placebo in the treatment of heartburn of pregnancy in ninety-two patients completing 7 days of therapy. Syn-Ergel was significantly better (p 0.001) in all groups of pre-treatment pain severity in relieving the symptoms, and had a longer duration of action, than the active placebo. Complete relief of pain was achieved in 79.5% of Syn-Ergel treatments with a further 10% of treatments resulting in marked easing of discomfort at 1 hour following administration. The corresponding figures for the \u2018active placebo\u2019 were 56% and 20%.<\/jats:p>\n                  <jats:p>The combination of an antacid and a protective mucosal coating agent would appear to be a useful approach in the treatment of heartburn of pregnancy.<\/jats:p>","DOI":"10.1177\/030006057800600215","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T18:27:30Z","timestamp":1409855250000},"page":"147-151","source":"Crossref","is-referenced-by-count":3,"title":["Randomized Controlled Trial of Syn-Ergel and an Active Placebo in the Treatment of Heartburn of Pregnancy"],"prefix":"10.1177","volume":"6","author":[{"given":"R W","family":"Shaw","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University of Birmingham, England"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1978,3,1]]},"reference":[{"key":"bibr1-030006057800600215","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1973.tb02133.x"},{"key":"bibr2-030006057800600215","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/j.1471-0528.1958.tb08603.x","volume":"65","author":"Barr W","year":"1958","journal-title":"The Journal of Obstetrics and Gynaecology of the British Empire"},{"key":"bibr3-030006057800600215","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197004162821602"},{"key":"bibr4-030006057800600215","first-page":"1830","volume":"38","author":"Ranft M","year":"1965","journal-title":"Munchener Medizinische Wochenschrift"},{"key":"bibr5-030006057800600215","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1935.tb06400.x"},{"key":"bibr6-030006057800600215","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1136\/gut.13.4.318","volume":"13","author":"Stanciu C","year":"1972","journal-title":"Gut"},{"key":"bibr7-030006057800600215","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(41)90172-2"},{"key":"bibr8-030006057800600215","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(67)80064-7"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057800600215","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057800600215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:49:12Z","timestamp":1777459752000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006057800600215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,3]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1978,3]]}},"alternative-id":["10.1177\/030006057800600215"],"URL":"https:\/\/doi.org\/10.1177\/030006057800600215","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,3]]}}}