{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:09:29Z","timestamp":1777727369829,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1978,5,1]],"date-time":"1978-05-01T00:00:00Z","timestamp":262828800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1978,5]]},"abstract":"<jats:p>Out of 24 patients with suspected moderate to severe infections and treated with the semisynthetic aminoglycoside netilmicin, 11 patients had decreased renal function. Non-bacterial aetiology was present in five cases. There was good netilmicin effect in 10 cases, indeterminate effect in 6 cases (due to simultaneously given other antibiotics) and failure in 3 cases. Pharmacokinetic parameters were studied. Curves are given for serum concentration patterns relative to creatinine clearance, and serum half lives are calculated in renal dysfunction.<\/jats:p>\n                  <jats:p>In this series of very ill patients including impaired renal function, netilmicin proved to be an efficient antibiotic with low toxicity. Only one transient minor vestibular abnormality in an 80-year-old man with concomitant diuretic medication was registered.<\/jats:p>","DOI":"10.1177\/030006057800600310","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T18:25:18Z","timestamp":1409855118000},"page":"226-234","source":"Crossref","is-referenced-by-count":5,"title":["Netilmicin Treatment of Serious Infections in Patients with Renal Insufficiency"],"prefix":"10.1177","volume":"6","author":[{"given":"Marianne","family":"Jonsson","sequence":"first","affiliation":[{"name":"Assistant Professor, Assistant Chief Physician, Roslagstull Hospital, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inger","family":"Julander","sequence":"additional","affiliation":[{"name":"A ssistant Physician, R oslagstull Hospital, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6sta","family":"Tunevall","sequence":"additional","affiliation":[{"name":"Professor of Bacteriology, Clinical Bacteriological Laboratory, Serafimerlasarettet and Roslagstull Hospital, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knut","family":"Haeger","sequence":"additional","affiliation":[{"name":"Fellow of Surgery, Area Medical Director, Schering Corporation, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1978,5,1]]},"reference":[{"key":"bibr1-030006057800600310","first-page":"55","volume":"15","author":"Alfthan O","year":"1978","journal-title":"Clinical Trials Journal"},{"key":"bibr2-030006057800600310","doi-asserted-by":"crossref","unstructured":"Brummett R, Fox K, Brown R, Himes D (1978) Comparative ototoxic liability of Sch 20569 and","DOI":"10.1001\/archotol.1978.00790100033007"},{"key":"bibr3-030006057800600310","unstructured":"Buckwold F J, Ronald A R, Lank B, Fox L, Harding G, Gurwith M (1977) Clinical trial of netilmicin.\n                      10th International Congress of Chemotherapy: Abstracts.\n                      No. 382."},{"key":"bibr4-030006057800600310","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.11.5.821"},{"key":"bibr5-030006057800600310","unstructured":"Christensson P, Eden T, Frolov I, Jonsson M, Juhlin I, Julander I, Nordstrom L, Sk\u00e5nsberg P, Tjernstr\u00f6m \u00d6, Tunevall G, Wallmark E (1977) Efficacy and tolerance of netilmicin in moderate to severe infections.\n                      10th International Congress of Chemotherapy: Abstracts\n                      No. 383."},{"key":"bibr6-030006057800600310","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/119.4-5.427"},{"key":"bibr7-030006057800600310","unstructured":"Denneberg T, Ekberg M, Juhlin I (1978) Netilmicin in U.T.I. in complicated nephrological cases. (To be published)."},{"key":"bibr8-030006057800600310","unstructured":"Edelstein P H, Meyer R D (1977) Netilmicin therapy of serious Gram-negative bacillary infections.\n                      10th International Congress of Chemotherapy: Abstracts\n                      No. 381."},{"key":"bibr9-030006057800600310","unstructured":"Ed\u00e9n T, Haeger K, Sk\u00e5nsberg P (1978) Netilmicin in severe infections \u2013 a randomized comparison with gentamicin. (To be published)."},{"key":"bibr10-030006057800600310","unstructured":"Federspil P (1978) Ototoxicity and nephrotoxicity of netilmicin. (To be published)."},{"key":"bibr11-030006057800600310","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.10.3.526"},{"key":"bibr12-030006057800600310","unstructured":"Henriksson P, Svenningsen N, Haeger K (1978) Netilmicin in serious infections in neonates. (To be published)."},{"key":"bibr13-030006057800600310","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/124.Supplement_1.S130"},{"key":"bibr14-030006057800600310","doi-asserted-by":"publisher","DOI":"10.1007\/BF01646979"},{"key":"bibr15-030006057800600310","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.10.1.139"},{"key":"bibr16-030006057800600310","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.10.5.845"},{"key":"bibr17-030006057800600310","unstructured":"Madsen P O, Hoyme U (1977) Netilmicin and tobramycin in the therapy of complicated urinary tract infections.\n                      10th International Congress of Chemotherapy: Abstracts\n                      No. 384."},{"key":"bibr18-030006057800600310","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.9.4.595"},{"key":"bibr19-030006057800600310","first-page":"457","volume":"78","author":"Sabath L D","year":"1971","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"bibr20-030006057800600310","unstructured":"Schering Corp. 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