{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:09:41Z","timestamp":1777727381085,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1978,7,1]],"date-time":"1978-07-01T00:00:00Z","timestamp":268099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1978,7]]},"abstract":"<jats:p>Amikacin was used in the treatment of various Gram-negative infections in sixty-six children ranging in age from two days to thirteen years. Over 72% of the infections treated were classified as severe and the remainder were moderate. Among infections in which the site of origin was the urinary or gastro-intestinal tract, amikacin achieved thirty-eight (95%) complete or partial cures in forty patients. In respiratory tract infections, amikacin completely or partially cured six (75%) out of eight patients. The remaining eighteen infections involved skin, soft tissue and other miscellaneous categories in which amikacin therapy resulted in seventeen (94%) complete or partial cures. Overall, amikacin achieved fifty-four complete cures and seven clinical or bacteriological cures in sixty-six patients, which represents an 82% complete cure rate and 10% partial cure rate for all the patients in the study.<\/jats:p>","DOI":"10.1177\/030006057800600402","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T12:33:15Z","timestamp":1484051595000},"page":"257-265","source":"Crossref","is-referenced-by-count":0,"title":["Amikacin in Gram-Negative Paediatric Infections"],"prefix":"10.1177","volume":"6","author":[{"given":"Hugo","family":"Trujillo","sequence":"first","affiliation":[{"name":"Children's Hospital, Department of Paediatrics, Faculty of Medicine, University of Antioquia, Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Manotas","sequence":"additional","affiliation":[{"name":"Children's Hospital, Department of Paediatrics, Faculty of Medicine, University of Antioquia, Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Ivan","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Children's Hospital, Department of Paediatrics, Faculty of Medicine, University of Antioquia, Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro","family":"Uribe","sequence":"additional","affiliation":[{"name":"Children's Hospital, Department of Paediatrics, Faculty of Medicine, University of Antioquia, Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Agudelo","sequence":"additional","affiliation":[{"name":"Children's Hospital, Department of Paediatrics, Faculty of Medicine, University of Antioquia, Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen Tulia","family":"Zapata","sequence":"additional","affiliation":[{"name":"Children's Hospital, Department of Paediatrics, Faculty of Medicine, University of Antioquia, Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Isabel","family":"Zuluaga","sequence":"additional","affiliation":[{"name":"Children's Hospital, Department of Paediatrics, Faculty of Medicine, University of Antioquia, Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther Luisa","family":"de Vidal","sequence":"additional","affiliation":[{"name":"Children's Hospital, Department of Paediatrics, Faculty of Medicine, University of Antioquia, Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1978,7,1]]},"reference":[{"key":"bibr1-030006057800600402","doi-asserted-by":"publisher","DOI":"10.1177\/030006057500300604"},{"key":"bibr2-030006057800600402","doi-asserted-by":"publisher","DOI":"10.1177\/030006057500300401"},{"key":"bibr3-030006057800600402","doi-asserted-by":"publisher","DOI":"10.1177\/030006057500300605"},{"key":"bibr4-030006057800600402","doi-asserted-by":"publisher","DOI":"10.1177\/030006057600400101"},{"key":"bibr5-030006057800600402","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/135.Supplement_2.S406"},{"key":"bibr6-030006057800600402","first-page":"205","volume":"2","author":"Trujillo H","year":"1975","journal-title":"Investigations of International Medicine"},{"key":"bibr7-030006057800600402","unstructured":"Yow M D (1977) An overview of paediatric experience with amikacin. The American Journal of Medicine, June 1977 Supplement (US Amikacin Symposium), 167."}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057800600402","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057800600402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:49:16Z","timestamp":1777459756000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006057800600402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,7]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1978,7]]}},"alternative-id":["10.1177\/030006057800600402"],"URL":"https:\/\/doi.org\/10.1177\/030006057800600402","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,7]]}}}