{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:10:15Z","timestamp":1777727415218,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1978,9,1]],"date-time":"1978-09-01T00:00:00Z","timestamp":273456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1978,9]]},"abstract":"<jats:p>On the grounds of pharmacological properties and preliminary clinical trials the efficacy of the new antidepressant caroxazone was compared to amitriptyline in the management of depression.<\/jats:p>\n                  <jats:p>Forty patients mostly suffering from a neurotic or anxious-neurotic depression were admitted to a double-blind trial. All patients completed the study. The Hamilton Rating Scale for Depression was used for the clinical assessment at the beginning, during and at the end of treatment.<\/jats:p>\n                  <jats:p>The trial lasted three weeks. A significant improvement was seen for both drugs after seven days on most symptom scores and on total symptom score. No significant differences were found either at seven days or at the end of treatment between the two drugs. There were no significant differences in the incidence and severity of side-effects.<\/jats:p>\n                  <jats:p>In conclusion, caroxazone appears as an effective and well tolerated drug in the treatment of depression.<\/jats:p>","DOI":"10.1177\/030006057800600507","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T16:55:45Z","timestamp":1484326545000},"page":"388-394","source":"Crossref","is-referenced-by-count":12,"title":["A Comparative Double-Blind Trial of the New Antidepressant Caroxazone and Amitriptyline"],"prefix":"10.1177","volume":"6","author":[{"given":"S","family":"Cecchini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Petri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Ardito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S R","family":"Bareggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Torriti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1978,9,1]]},"reference":[{"key":"bibr1-030006057800600507","unstructured":"Avesani A, Bareggi S R, Torriti A (1978) Comparison of amitriptyline and caroxazone in depressed out-patients. Submitted to\n                      British Journal of Psychiatry\n                      ."},{"key":"bibr2-030006057800600507","doi-asserted-by":"publisher","DOI":"10.1007\/BF02144859"},{"key":"bibr3-030006057800600507","first-page":"340","volume":"39","author":"Bertolino A","year":"1973","journal-title":"Neopsichiatria"},{"key":"bibr4-030006057800600507","unstructured":"Broglia S, Pellegrini V (1978) A double-blind comparative trial with caroxazone and amitriptyline in depressed in-patients. Submitted to\n                      International Pharmacopsychiatry\n                      ."},{"key":"bibr5-030006057800600507","first-page":"613","volume":"38","author":"Fanali A","year":"1972","journal-title":"Neopsichiatria"},{"key":"bibr6-030006057800600507","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"bibr7-030006057800600507","first-page":"57","volume":"27","author":"Kemali D","year":"1972","journal-title":"Acta Neurologica"},{"key":"bibr8-030006057800600507","first-page":"403","volume":"27","author":"Lo Grasso G","year":"1972","journal-title":"Acta Neurologica"},{"key":"bibr9-030006057800600507","unstructured":"Martini A, Bonollo L, Nicolis F B Interaction between tyramine and a new reversible MAOI antidepressant in healthy volunteers. (In preparation)."},{"key":"bibr10-030006057800600507","unstructured":"Moretti A, Caccia C, Martini A, Amico A Inhibitory effect of caroxazone on monoamineoxidase in healthy volunteers. (In preparation)."},{"key":"bibr11-030006057800600507","first-page":"3","volume":"98","author":"Mastrosimone F","year":"1974","journal-title":"Rivista Sperimentale di Freniatria"},{"key":"bibr12-030006057800600507","unstructured":"Moretti A, Caccia C (1977) The effect of caroxazone on monoamine metabolism in rat brain. Communication at the\n                      Sixth International Meeting of the International Society for Neurochemistry\n                      , Copenhagen, August 21-26."},{"key":"bibr13-030006057800600507","first-page":"36","volume":"113","author":"Moretti A","year":"1974","journal-title":"Bollettino Chimico Farmaceutico"},{"key":"bibr14-030006057800600507","first-page":"149","volume":"38","author":"Pariante F","year":"1972","journal-title":"Neopsichiatria"},{"key":"bibr15-030006057800600507","unstructured":"Ponzio F, Curcio M, Brunello N, Algeri S (1977) Effect of caroxazone, a new antidepressant drug on catecholamine metabolism in rat CNS. Communication at the\n                      Sixth International Meeting of the International Society for Neurochemistry\n                      , Copenhagen, August 21-26."},{"key":"bibr16-030006057800600507","doi-asserted-by":"publisher","DOI":"10.1177\/009127007701701001"},{"key":"bibr17-030006057800600507","unstructured":"Rosadini G, Fassina G F, Gasparetto B, Sannita W G (1977) Communication at the\n                      Ninth International Congress of Electroencephalography and Clinical Neurophysiology\n                      , Amsterdam, September 4."},{"key":"bibr18-030006057800600507","first-page":"643","volume":"19","author":"Suchowsky G K","year":"1969","journal-title":"Arzneimittel Forschung"},{"key":"bibr19-030006057800600507","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(69)90192-7"},{"issue":"2","key":"bibr20-030006057800600507","first-page":"332","volume":"182","author":"Suchowsky G K","year":"1969","journal-title":"Archives Internationales de Pharmacodynamie et de Th\u00e9rapie"},{"key":"bibr21-030006057800600507","first-page":"151","volume":"98","author":"Vescovini L","year":"1974","journal-title":"Rivista Sperimentale di Freniatria"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057800600507","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057800600507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:49:21Z","timestamp":1777459761000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006057800600507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,9]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1978,9]]}},"alternative-id":["10.1177\/030006057800600507"],"URL":"https:\/\/doi.org\/10.1177\/030006057800600507","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,9]]}}}