{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:11:12Z","timestamp":1777727472943,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1979,1,1]],"date-time":"1979-01-01T00:00:00Z","timestamp":283996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1979,1]]},"abstract":"<jats:p>Twenty-eight medical specialists (internists, rheumatologists) selected 102 primarily arthritic patients for a two-week efficacy and safety field study of salicylsalicylic acid. Data were gathered on pain, morning stiffness, range of motion, serum salicylate concentration, erythrocyte sedimentation rate (ESR) and gastro-intestinal bleeding before and after a 15-day drug trial. Results showed a 67% favourable clinical response in the physician's global evaluation and a 60% improvement in pain; the drug itself was well tolerated by 96% of patients. Response correlations with morning stiffness and range of motion were equivocal. Of fifty-four patients examined before and after treatment for intestinal bleeding, only two (3.7%) had detectable faecal blood loss. Good clinical response had a statistically significant association with serum drug concentrations of 13.6 to 13.8 mg%; unsatisfactory response was noted in those patients with mean serum salicylate levels of 8.6 mg%. ESR decreased or was unchanged in thirty-five patients with satisfactory clinical response and in fourteen patients with unsatisfactory response.<\/jats:p>","DOI":"10.1177\/030006057900700114","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T14:59:06Z","timestamp":1484146746000},"page":"90-95","source":"Crossref","is-referenced-by-count":6,"title":["Salicylsalicylic Acid Revisited: A Multicentre Study"],"prefix":"10.1177","volume":"7","author":[{"given":"O N","family":"R\u00e9","sequence":"first","affiliation":[{"name":"Director, Medical Services, Riker Laboratories, Inc., Northridge, CA 93124, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1979,1,1]]},"reference":[{"key":"bibr1-030006057900700114","unstructured":"Brewer E J (1966) Proceedings of the Conference on Effects of Chronic Salicylate Administration. Edited by Lamont-Havers R M, Wagner B W. Washington, DC, US Government Printing Office, p. 26\u201339."},{"key":"bibr2-030006057900700114","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1979.tb01658.x"},{"key":"bibr3-030006057900700114","doi-asserted-by":"publisher","DOI":"10.1185\/03007997709110162"},{"key":"bibr4-030006057900700114","doi-asserted-by":"publisher","DOI":"10.1177\/028418517101100107"},{"key":"bibr5-030006057900700114","first-page":"353","volume":"1","author":"French I W","year":"1978","journal-title":"Clinical Therapeutics"},{"key":"bibr6-030006057900700114","first-page":"911","volume":"74","author":"Leonards J R","year":"1969","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"bibr7-030006057900700114","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600540703"},{"key":"bibr8-030006057900700114","doi-asserted-by":"publisher","DOI":"10.1185\/03007997809111914"},{"key":"bibr9-030006057900700114","unstructured":"Marshall N W, Lewis H E (1978) Report of a multicentre evaluation of Disalcid (salsalate). On file, Medical Services Department, Riker Laboratories, Inc., Northridge, CA 91324."},{"key":"bibr10-030006057900700114","first-page":"1074","volume":"74","author":"Nordqvist P","year":"1965","journal-title":"Nordisk Medicin"},{"key":"bibr11-030006057900700114","first-page":"2029","volume":"70","author":"Paris L","year":"1963","journal-title":"Clinical Medicine"},{"key":"bibr12-030006057900700114","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780140412"},{"key":"bibr13-030006057900700114","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-196407000-00006"},{"key":"bibr14-030006057900700114","first-page":"352","volume":"79","author":"Thune S","year":"1968","journal-title":"Nordisk Medicin"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057900700114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057900700114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:49:29Z","timestamp":1777459769000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006057900700114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,1]]}},"alternative-id":["10.1177\/030006057900700114"],"URL":"https:\/\/doi.org\/10.1177\/030006057900700114","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,1]]}}}