{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:11:53Z","timestamp":1777727513662,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1979,9,1]],"date-time":"1979-09-01T00:00:00Z","timestamp":304992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1979,9]]},"abstract":"<jats:p>In a general practice study using ketoprofen (Orudis\u00ae) in a twice-daily dosage regimen for the treatment of patients with articular and non-articular rheumatic conditions, data were collected on 2, 644 patients, over one-third of whom had been previously treated with other anti-rheumatic preparations. More than 80% showed a clinical improvement and the overall incidence of side-effects was relatively low. Three patients suffered a haematemesis \u2013 the most serious side-effect encountered. It was concluded that 50 mg or 100 mg twice-daily therapy was equally as effective as the 50 mg thrice daily regimen previously recommended and that the tolerability of ketoprofen was not adversely affected by this concentration of the daily requirement.<\/jats:p>","DOI":"10.1177\/030006057900700502","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T13:23:55Z","timestamp":1484141035000},"page":"344-350","source":"Crossref","is-referenced-by-count":6,"title":["Ketoprofen (Orudis\u00ae) Twice Daily Dosage in Arthritis and Tissue Injuries: A General Practice Study"],"prefix":"10.1177","volume":"7","author":[{"given":"P G","family":"Baker","sequence":"first","affiliation":[{"name":"May & Baker Limited, Dagenham, Essex, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Goulton","sequence":"additional","affiliation":[{"name":"May & Baker Limited, Dagenham, Essex, England"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1979,9,1]]},"reference":[{"key":"bibr1-030006057900700502","doi-asserted-by":"publisher","DOI":"10.1136\/ard.32.1.62"},{"key":"bibr2-030006057900700502","first-page":"1","volume":"33","author":"Goulton J","year":"1979","journal-title":"British Journal of Clinical Practice"},{"key":"bibr3-030006057900700502","doi-asserted-by":"crossref","unstructured":"Guyonnet J C, Julou L (1976) Relationship between the inhibitory activity on \u2018RCS\u2019 and prostaglandins synthesis and the anti-inflammatory activity of ketoprofen and several other nonsteroidal anti-inflammatory agents. Rheumatology and Rehabilitation Suppl 11.","DOI":"10.1093\/rheumatology\/15.5.11"},{"key":"bibr4-030006057900700502","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5837.398"},{"key":"bibr5-030006057900700502","first-page":"10","volume":"28","author":"Hart F D","year":"1972","journal-title":"Practitioner"},{"key":"bibr6-030006057900700502","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6017.1048"},{"key":"bibr7-030006057900700502","doi-asserted-by":"crossref","unstructured":"Kennedy A C (1976) Ketoprofen in the treatment of rheumatoid arthritis. Rheumatology and Rehabilitation Suppl 34.","DOI":"10.1093\/rheumatology\/15.5.34"},{"key":"bibr8-030006057900700502","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5884.82"},{"key":"bibr9-030006057900700502","first-page":"735","volume":"31","author":"Populaire P","year":"1973","journal-title":"Annales Pharmaceutiques Franc\u00e1ises"},{"key":"bibr10-030006057900700502","doi-asserted-by":"publisher","DOI":"10.1185\/03007997809111919"},{"key":"bibr11-030006057900700502","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/12.2.62"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057900700502","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057900700502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:49:38Z","timestamp":1777459778000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006057900700502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,9]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1979,9]]}},"alternative-id":["10.1177\/030006057900700502"],"URL":"https:\/\/doi.org\/10.1177\/030006057900700502","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,9]]}}}