{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:12:59Z","timestamp":1777727579358,"version":"3.51.4"},"reference-count":4,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1979,11,1]],"date-time":"1979-11-01T00:00:00Z","timestamp":310262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1979,11]]},"abstract":"<jats:p>A clinical study was undertaken, in twenty-four patients with atrophic vaginal changes, to assess the efficacy and the acceptability of treatment with Ortho-Gynest vaginal suppositories, which have as their active constituent the naturally occurring substance oestriol.<\/jats:p>\n                  <jats:p>A regenerative effect on the vaginal epithelium could be objectively demonstrated by an increase in the proportion of superficial cells following treatment. Changes in the vaginal epithelium were accompanied by a diminution in the incidence of infection and inflammation.<\/jats:p>\n                  <jats:p>Subjective complaints such as dyspareunia, pruritis and kraurosis vulvae, which could also be ascribed to a relative oestrogen deficiency, responded well to treatment.<\/jats:p>","DOI":"10.1177\/030006057900700618","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T23:13:02Z","timestamp":1484608382000},"page":"569-572","source":"Crossref","is-referenced-by-count":2,"title":["The Treatment of Atrophic Vaginal Conditions with Ortho-Gynest: A Pilot Study"],"prefix":"10.1177","volume":"7","author":[{"given":"K E","family":"Karoussos","sequence":"first","affiliation":[{"name":"Cilag-Chemie Limited, Schaffhausen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Studer","sequence":"additional","affiliation":[{"name":"Cilag-Chemie Limited, Schaffhausen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H J","family":"Wyss","sequence":"additional","affiliation":[{"name":"Professor, Department of Gynaecology, University of Basle, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1979,11,1]]},"reference":[{"key":"bibr1-030006057900700618","first-page":"2","volume":"43","author":"Borgli N E","year":"1975","journal-title":"Acta Obstetricia et Gynaecologica Scandinavica Suppl"},{"key":"bibr2-030006057900700618","doi-asserted-by":"publisher","DOI":"10.1159\/000398277"},{"issue":"7","key":"bibr3-030006057900700618","first-page":"513","volume":"71","author":"Delacroix P","year":"1976","journal-title":"Revue Fran\u00e7aise de Gyn\u00e9cologie et d'Obst\u00e9trique"},{"key":"bibr4-030006057900700618","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1978.03280430054016"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057900700618","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006057900700618","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:49:48Z","timestamp":1777459788000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006057900700618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,11]]},"references-count":4,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1979,11]]}},"alternative-id":["10.1177\/030006057900700618"],"URL":"https:\/\/doi.org\/10.1177\/030006057900700618","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,11]]}}}