{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:14:38Z","timestamp":1777727678842,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1980,9,1]],"date-time":"1980-09-01T00:00:00Z","timestamp":336614400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1980,9]]},"abstract":"<jats:p>Disalcid\u00ae, a salicylic acid pro-drug, was administered for 3 months to eighteen rheumatoid arthritis patients, with monitoring of clinical response, side-effects and laboratory changes. The drug produced a satisfactory to excellent response in fourteen patients and was unsatisfactory in four.<\/jats:p>\n                  <jats:p>Gastric side-effects occurred in three patients and allergic reaction in one. Serum salicylic acid concentrations were adequately maintained between 15 to 25 mg\/100 ml.<\/jats:p>\n                  <jats:p>Funduscopic monitoring revealed one retinal defect in a patient with hypertension. Laboratory examinations, blood chemistry and urine analyses remained within normal limits during the 12-week trial.<\/jats:p>","DOI":"10.1177\/030006058000800506","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T08:16:44Z","timestamp":1484468204000},"page":"339-342","source":"Crossref","is-referenced-by-count":3,"title":["Long-Term Management of Rheumatoid Arthritis with Disalcid\u00ae"],"prefix":"10.1177","volume":"8","author":[{"given":"Prim dr Franc","family":"Fazarinc","sequence":"first","affiliation":[{"name":"Chief, Department of Medicine, General Hospital, Calje, 63000 Yugoslavia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen N","family":"Steen","sequence":"additional","affiliation":[{"name":"Professor of Anesthesiology, UCLA School of Medicine, Harbor General Hospital Campus, Torrance, California 90509, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1980,9,1]]},"reference":[{"key":"bibr1-030006058000800506","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1979.tb01658.x"},{"key":"bibr2-030006058000800506","doi-asserted-by":"publisher","DOI":"10.1185\/03007997709110162"},{"key":"bibr3-030006058000800506","doi-asserted-by":"publisher","DOI":"10.1177\/028418517101100107"},{"key":"bibr4-030006058000800506","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8707(70)90040-7"},{"key":"bibr5-030006058000800506","unstructured":"Hepatotoxicity Fogarty International Conference Meetings (1977) F-D-C Reports (\u2018The Pink Sheet\u2019) 39: T & G-11-12 (21 November)."},{"key":"bibr6-030006058000800506","first-page":"911","volume":"74","author":"Leonards J R","year":"1969","journal-title":"Journal of Clinical and Laboratory Medicine"},{"key":"bibr7-030006058000800506","doi-asserted-by":"publisher","DOI":"10.1185\/03007997809111914"},{"key":"bibr8-030006058000800506","unstructured":"Nordqvist P (1964) Salicylsalicylic acid in the treatment of rheumatoid diseases and pain.\n                      Lecture held at the yearly congress of the Swedish Medical Society Stockholm (Nov 26)\n                      ."},{"key":"bibr9-030006058000800506","first-page":"31","volume":"6","author":"Nordqvist P","year":"1976","journal-title":"Aktnelle Gerontologie"},{"key":"bibr10-030006058000800506","doi-asserted-by":"publisher","DOI":"10.1038\/219068a0"},{"key":"bibr11-030006058000800506","doi-asserted-by":"publisher","DOI":"10.1177\/030006057900700114"},{"key":"bibr12-030006058000800506","doi-asserted-by":"publisher","DOI":"10.1185\/03007997809111915"},{"key":"bibr13-030006058000800506","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1979262145"},{"key":"bibr14-030006058000800506","unstructured":"Singleton P T (1980) Salsalate: Its role in the management of rheumatic disease. Review of the literature and comment.\n                      (Unpublished manuscript)\n                      ."},{"key":"bibr15-030006058000800506","first-page":"352","volume":"79","author":"Thune S","year":"1968","journal-title":"Nordisk Medicin"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058000800506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058000800506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:50:03Z","timestamp":1777459803000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006058000800506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,9]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1980,9]]}},"alternative-id":["10.1177\/030006058000800506"],"URL":"https:\/\/doi.org\/10.1177\/030006058000800506","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,9]]}}}