{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:15:08Z","timestamp":1777727708782,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1980,11,1]],"date-time":"1980-11-01T00:00:00Z","timestamp":341884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1980,11]]},"abstract":"<jats:p>A post-marketing surveillance study of Euhypnos\u00ae Forte (temazepam 20 mg) capsules for the treatment of insomnia in 10,057 patients previously unresponsive to other hypnotics given in conventional doses. Patients were prescribed a nightly dose of 40 or 60 mg, but 95% actually took 40 mg. At 2 weeks, 89% of patients found the treatment effective, as did 95% at 3 months. Hangover, severe enough to stop treatment, occurred in less than 3% of patients, and other adverse reactions such as headache, dreams, gastro-intestinal disturbance and hangover symptoms were reported by only 6% of patients at 2 weeks and 4% at 3 months. The most common reason for stopping treatment was the patient having no further need of hypnotics. Euhypnos Forte was effective in 88% of 3,800 patients who had found nitrazepam unsatisfactory and 90% of 1,013 patients unresponsive to barbiturates.<\/jats:p>","DOI":"10.1177\/030006058000800616","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T23:28:57Z","timestamp":1484177337000},"page":"446-452","source":"Crossref","is-referenced-by-count":3,"title":["Euhypnos\u00ae Forte, High Dose Temazepam for Resistant Insomnia: Post-Marketing Surveillance in 10,057 Patients Unresponsive to Conventional Hypnotic Dosage"],"prefix":"10.1177","volume":"8","author":[{"given":"L Keith","family":"Fowler","sequence":"first","affiliation":[{"name":"Sometime Medical Director, Montedison Pharmaceuticals Limited, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen","family":"Schiller","sequence":"additional","affiliation":[{"name":"Clinical Research Associate, Farmitalia Carlo Erba Limited, Kingmaker House, Station Road, Barnet, Hertfordshire EN5 1NU, England"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1980,11,1]]},"reference":[{"key":"bibr1-030006058000800616","first-page":"406","volume":"8","author":"Carrington E A","year":"1980","journal-title":"IRCS Medical Science"},{"key":"bibr2-030006058000800616","doi-asserted-by":"publisher","DOI":"10.1177\/030006057700500502"},{"key":"bibr3-030006058000800616","doi-asserted-by":"publisher","DOI":"10.1177\/030006058000800410"},{"key":"bibr4-030006058000800616","doi-asserted-by":"publisher","DOI":"10.1007\/BF00562455"},{"key":"bibr5-030006058000800616","first-page":"2113","volume":"26","author":"Hindmarch I","year":"1976","journal-title":"Arzneimittel-Forschung (Drug research)"},{"key":"bibr6-030006058000800616","unstructured":"Hindmarch I, Parrot A C, Hickey B, Clyde C (1980) An investigation into the effect of temazepam (40 mg and 60 mg) upon sleep and early morning behaviour in normal subjects. Drugs under Clinical and Experimental Research (In press)."},{"key":"bibr7-030006058000800616","doi-asserted-by":"publisher","DOI":"10.1177\/030006057900700407"},{"key":"bibr8-030006058000800616","doi-asserted-by":"publisher","DOI":"10.1177\/030006057900700406"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058000800616","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058000800616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:50:09Z","timestamp":1777459809000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006058000800616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,11]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1980,11]]}},"alternative-id":["10.1177\/030006058000800616"],"URL":"https:\/\/doi.org\/10.1177\/030006058000800616","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,11]]}}}