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Median pain relief over the entire study was rated as good, very good or excellent in eleven patients (55%) and poor to fair in the remaining nine patients (45%). Global assessments were as follows: good to very good \u2013 twelve patients; poor to fair \u2013 eight patients. Ten of the twenty patients treated reported side-effects (sedation, light-headedness, dizziness, insomnia and headache) ranging from mild to severe. No drug-related abnormalities with respect to blood pressure, body-weight or laboratory data were evident.<\/jats:p>","DOI":"10.1177\/030006058100900206","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T11:33:40Z","timestamp":1484307220000},"page":"120-123","source":"Crossref","is-referenced-by-count":5,"title":["An Open Evaluation of Oral Butorphanol as Long-Term Therapy in Out-Patients Suffering from Moderate to Severe Chronic Pain"],"prefix":"10.1177","volume":"9","author":[{"given":"Ricardo","family":"Rangel-Guerra","sequence":"first","affiliation":[{"name":"Professor and Head, Division of Neurology, Hospital Universitario, Universidad Aut\u00f3noms de Nuevo Le\u00f3n Apdo. Postal 767, Monterrey, N.L., M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1981,3,1]]},"reference":[{"key":"bibr1-030006058100900206","volume-title":"Pharmacological and Biochemical Properties of Drug Substances","volume":"2","author":"Caruso F S","year":"1979"},{"key":"bibr2-030006058100900206","first-page":"1","volume":"9","author":"De La Garza J","year":"1980","journal-title":"Journal of International Medical Research"},{"key":"bibr3-030006058100900206","doi-asserted-by":"publisher","DOI":"10.1177\/030006057800600104"},{"key":"bibr4-030006058100900206","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-197816060-00001"},{"key":"bibr5-030006058100900206","first-page":"139","author":"Jasinski D R","year":"1975","journal-title":"Problems of Drug Dependence"},{"key":"bibr6-030006058100900206","first-page":"112","author":"Jasinski D R","year":"1976","journal-title":"Problems of Drug Dependence"},{"key":"bibr7-030006058100900206","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1979.tb06362.x"},{"key":"bibr8-030006058100900206","first-page":"105","volume":"22","author":"Kliman A","year":"1977","journal-title":"Current Therapeutic Research"},{"key":"bibr9-030006058100900206","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1976196738"},{"key":"bibr10-030006058100900206","first-page":"231","volume":"220","author":"Pircio A W","year":"1976","journal-title":"Archives Internationales de Pharmacodynamic et de Th\u00e9rapie"},{"key":"bibr11-030006058100900206","first-page":"249","volume":"25","author":"Smith B E","year":"1979","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"bibr12-030006058100900206","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198002143020705"},{"key":"bibr13-030006058100900206","first-page":"186","volume":"22","author":"Vargas-Arreola F","year":"1977","journal-title":"Current Therapeutic Research"},{"key":"bibr14-030006058100900206","first-page":"239","volume":"10","author":"Young R E S","year":"1980","journal-title":"Journal of Medicine"},{"key":"bibr15-030006058100900206","doi-asserted-by":"publisher","DOI":"10.1185\/03007997909109418"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058100900206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058100900206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:50:13Z","timestamp":1777459813000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006058100900206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,3]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,3]]}},"alternative-id":["10.1177\/030006058100900206"],"URL":"https:\/\/doi.org\/10.1177\/030006058100900206","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,3]]}}}