{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:15:51Z","timestamp":1777727751373,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1981,5,1]],"date-time":"1981-05-01T00:00:00Z","timestamp":357523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1981,5]]},"abstract":"<jats:p>Lormetazepam (Noctamid\u00ae) at a dosage of 1 mg was compared with diazepam (Valium\u00ae) at a dosage of 5 mg in a 7-day double-blind study. The study involved fifty patients in the lormetazepam group and fifty patients in the diazepam group. All the patients were suffering from sleep disorders as a concomitant symptom of general diseases.<\/jats:p>\n                  <jats:p>Lormetazepam was significantly better than diazepam in the:<\/jats:p>\n                  <jats:p>Reduction of the time taken to fall asleep (p &lt; 0.05) Prolongation of the duration of uninterrupted sleep (p &lt; 0.05) Reduction of the frequency of awakening (p &lt; 0.05)<\/jats:p>\n                  <jats:p>Lormetazepam displayed no hang-over effects or other side-effects and, in this respect too, was significantly superior to diazepam (p &lt; 0.05).<\/jats:p>","DOI":"10.1177\/030006058100900309","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T08:01:01Z","timestamp":1484121661000},"page":"199-202","source":"Crossref","is-referenced-by-count":17,"title":["Comparative Efficacy of Lormetazepam (Noctamid\u00ae) and Diazepam (Valium\u00ae) in 100 Out-Patients with Insomnia"],"prefix":"10.1177","volume":"9","author":[{"given":"M Sastre y","family":"Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Medizinisch-Wissenschaftliche Hauptabteilung der Schering AG (Letter: Professor Dr W K R aff), D-1000 Berlin 65, Postfach 650311"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H-D","family":"Hentschel","sequence":"additional","affiliation":[{"name":"Medizinische Fakult\u00e4t der Technischen Universit\u00e4t M\u00fcnchen, Bodenschneidstra\u00dfe 9, 8182 Bad Wiessee, Kurklinik Winnerhof"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Fichte","sequence":"additional","affiliation":[{"name":"Fachbereich Physikochemie und Informatik der Schering AG (Leiter: Dr H R\u00f6pke), D-1000 Berlin 65, Postfach 650311"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1981,5,1]]},"reference":[{"key":"bibr1-030006058100900309","doi-asserted-by":"publisher","DOI":"10.1007\/BF00423189"},{"key":"bibr2-030006058100900309","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1974.tb02285.x"},{"key":"bibr3-030006058100900309","author":"Fern\u00e1ndez-Labriola R","year":"1981","journal-title":"Pharmakopsychiatrie"},{"key":"bibr4-030006058100900309","volume-title":"The Benzodiazepines","author":"Garattini S","year":"1973"},{"key":"bibr5-030006058100900309","first-page":"1","volume":"19","author":"Heidrich H","year":"1981","journal-title":"International Journal of Clinical Pharmacology, Therapy and Toxicology"},{"key":"bibr6-030006058100900309","volume-title":"Der gest\u00f6rte Schlaf","author":"Hentschel H-D","year":"1975"},{"key":"bibr7-030006058100900309","doi-asserted-by":"publisher","DOI":"10.1007\/BF03189433"},{"key":"bibr8-030006058100900309","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/clpt.1980.220","volume":"28","author":"H\u00fcmpel M","year":"1980","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"bibr9-030006058100900309","first-page":"223","volume":"4","author":"Jovanovic U J","year":"1980","journal-title":"Waking and Sleeping"},{"key":"bibr10-030006058100900309","unstructured":"Kurowski M (1979) Beziehung zwischen Pharmako-EEG and Pharmakokinetik von Lormetazepam. Inaugural-Dissertation zur Erlangung der Doktorw\u00fcrde im Fachbereich Pharmazie der Freien Universit\u00e4t Berlin."},{"key":"bibr11-030006058100900309","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6172.1167"},{"key":"bibr12-030006058100900309","volume-title":"Pharmacology of the States of Alertness","author":"Oswald I","year":"1979"},{"key":"bibr13-030006058100900309","first-page":"29","volume":"28","author":"Ott H","year":"1979","journal-title":"A naesthesist"},{"key":"bibr14-030006058100900309","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-67837-0_12"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058100900309","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058100900309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:50:17Z","timestamp":1777459817000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006058100900309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,5]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1981,5]]}},"alternative-id":["10.1177\/030006058100900309"],"URL":"https:\/\/doi.org\/10.1177\/030006058100900309","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,5]]}}}