{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:46:05Z","timestamp":1777725965670,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1983,1,1]],"date-time":"1983-01-01T00:00:00Z","timestamp":410227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1983,1]]},"abstract":"<jats:p>\n                    Platelet\n                    <jats:sup>14<\/jats:sup>\n                    C-serotonin release induced by collagen, and platelet malondialdehyde (M.D.A.) generation induced by thrombin were assessed in twenty patients with stable angina, before and after exercise with a bicycle ergometer. The patients received a single oral 200 mg dose of indobufen or placebo according to a crossover design in double-blind conditions. The M.D.A. concentration increased when exercise was carried out after placebo, whereas indobufen markedly inhibited M.D.A. production and\n                    <jats:sup>14<\/jats:sup>\n                    C-serotonin release.\n                  <\/jats:p>\n                  <jats:p>These results suggest that effort may be an important factor in activation of the platelet prostaglandin pathway and that the use of antithrombotic drugs may be appropriate in patients with angina.<\/jats:p>","DOI":"10.1177\/030006058301100102","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T14:11:36Z","timestamp":1484489496000},"page":"6-9","source":"Crossref","is-referenced-by-count":2,"title":["Platelet Release Reaction and Prostaglandin Pathway Activation in Angina Patients during Exercise: Effect of Indobufen"],"prefix":"10.1177","volume":"11","author":[{"given":"E M","family":"Pogliani","sequence":"first","affiliation":[{"name":"Istituto Clinica Medica I, Universit\u00e0 di Milano (Director: E E Polli, MD, PhD), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Fantasia","sequence":"additional","affiliation":[{"name":"Istituto Clinica Medica I, Universit\u00e0 di Milano (Director: E E Polli, MD, PhD), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Savino","sequence":"additional","affiliation":[{"name":"Istituto Clinica Medica I, Universit\u00e0 di Milano (Director: E E Polli, MD, PhD), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Montani","sequence":"additional","affiliation":[{"name":"Istituto Clinica Medica I, Universit\u00e0 di Milano (Director: E E Polli, MD, PhD), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1983,1,1]]},"reference":[{"key":"bibr1-030006058301100102","volume":"62","author":"Chierchia S","year":"1980","journal-title":"Circulation"},{"key":"bibr2-030006058301100102","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198001243020403"},{"key":"bibr3-030006058301100102","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(72)90070-6"},{"key":"bibr4-030006058301100102","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.47.2.353"},{"key":"bibr5-030006058301100102","first-page":"413","volume":"15","author":"Jerushalmy Z","year":"1965","journal-title":"Thrombosis and Diathesis Haemorrhagica"},{"key":"bibr6-030006058301100102","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.61.1.62"},{"key":"bibr7-030006058301100102","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1681116"},{"key":"bibr8-030006058301100102","first-page":"462A","volume":"27","author":"Lewy RI","year":"1979","journal-title":"Clinical Research"},{"key":"bibr9-030006058301100102","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198105213042106"},{"key":"bibr10-030006058301100102","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(80)90925-X"},{"key":"bibr11-030006058301100102","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(78)90162-4"},{"key":"bibr12-030006058301100102","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197805182982005"},{"key":"bibr13-030006058301100102","doi-asserted-by":"publisher","DOI":"10.1177\/030006058100900205"},{"key":"bibr14-030006058301100102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000207083","volume":"66","author":"Pogliani E","year":"1981","journal-title":"Haematologica"},{"key":"bibr15-030006058301100102","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198104233041703"},{"key":"bibr16-030006058301100102","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91693-7"},{"key":"bibr17-030006058301100102","first-page":"1589","volume":"42","author":"Sano T","year":"1980","journal-title":"Thrombosis and Haemostasis"},{"key":"bibr18-030006058301100102","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(79)90002-1"},{"key":"bibr19-030006058301100102","first-page":"167","volume":"88","author":"Smith JB","year":"1976","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"bibr20-030006058301100102","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V49.2.185.185"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058301100102","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058301100102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:44:22Z","timestamp":1777459462000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006058301100102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,1]]}},"alternative-id":["10.1177\/030006058301100102"],"URL":"https:\/\/doi.org\/10.1177\/030006058301100102","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,1]]}}}