{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:47:10Z","timestamp":1777726030806,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1984,3,1]],"date-time":"1984-03-01T00:00:00Z","timestamp":446947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1984,3]]},"abstract":"<jats:p>In a randomized double-blind parallel group study conducted in three centres the hypotensive activity of piretanide 6 mg b.i.d. was compared with that of hydrochlorothiazide (HCT) 25 mg b.i.d. and HCT 50 mg b.i.d. Ninety-three patients entered the study and sixty-one completed a 16\u2013week trial period. All three treatments produced a significant reduction in supine diastolic and systolic blood pressure after only 2 weeks of active treatment and this was maintained for the duration of the study. The mean maximal reduction in supine diastolic blood pressure was 18% in the piretanide group, 18\u00b78% in the HCT 25 mg b.i.d. group, and 20% in the HCT 50 mg b.i.d. group. The corresponding figures for the percentage of patients attaining a supine diastolic pressure below 95 mm Hg were 83%, 62% and 89%. There were no significant differences between the three groups.<\/jats:p>\n                  <jats:p>Side-effects were generally mild and transient, except for polyuria which was noted in all three groups but more commonly in the piretanide group. Two patients were withdrawn because of side-effects: one patient in the high dose HCT group developed severe postural symptoms; and one patient in the low dose HCT group was withdrawn because of restlessness, nausea, weakness, dizziness and somnolence.<\/jats:p>\n                  <jats:p>All three treatments caused a significant increase in serum uric acid concentrations. Four patients in each of the HCT groups developed hypokalemia, but no patients in the piretanide group did so.<\/jats:p>","DOI":"10.1177\/030006058401200203","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T22:57:26Z","timestamp":1484607446000},"page":"81-86","source":"Crossref","is-referenced-by-count":9,"title":["A Double-Blind Multicentre Study of Piretanide and Hydrochlorothiazide in Patients with Essential Hypertension"],"prefix":"10.1177","volume":"12","author":[{"given":"C","family":"Buckert","sequence":"first","affiliation":[{"name":"Jasperstrasse 2, 6900 Heidelberg-Emmertsgrund, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Muhlhausler","sequence":"additional","affiliation":[{"name":"Rappengasse 53, 6729 Rheinzabern, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Fratzer","sequence":"additional","affiliation":[{"name":"Hauptstrasse 54, 6719 Hettenleidelheim, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Verho","sequence":"additional","affiliation":[{"name":"Licentiate of Medicine, Hoechst Aktiengesellschaft, Medizinische Abteilung, Postfach 80 03 20, 6230 Frankfurt\/Main 80, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1984,3,1]]},"reference":[{"key":"bibr1-030006058401200203","first-page":"649","volume":"8","author":"Dols W","year":"1983","journal-title":"Current Therapeutic Research"},{"key":"bibr2-030006058401200203","doi-asserted-by":"crossref","unstructured":"Dols W, Verho M, Rangoonwala B (1984) Single and divided daily dose piretanide in the treatment of uncomplicated essential hypertension: a double-blind comparison with a combination of hydrochlorothiazide and amiloride. (Submitted for publication).","DOI":"10.1007\/BF00544079"},{"key":"bibr3-030006058401200203","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/bmj.1.6105.75","volume":"1","author":"Editorial","year":"1978","journal-title":"British Medical Journal"},{"key":"bibr4-030006058401200203","doi-asserted-by":"publisher","DOI":"10.1177\/000331977702800209"},{"key":"bibr5-030006058401200203","first-page":"468","volume":"30","author":"Gupta P S","year":"1981","journal-title":"Current Therapeutic Research"},{"key":"bibr6-030006058401200203","first-page":"124","volume":"262","author":"Handa M","year":"1983","journal-title":"Archives of International Pharmacodynamics"},{"key":"bibr7-030006058401200203","first-page":"121","volume":"10","author":"Johnston L C","year":"1970","journal-title":"Journal of Clinical Pharmacology"},{"key":"bibr8-030006058401200203","first-page":"1273","volume":"33","author":"Klaus E","year":"1983","journal-title":"Arzneimittel Forschung"},{"key":"bibr9-030006058401200203","first-page":"6","volume":"60","author":"Kommission der Deutschen Gesellschaft fur Kreislaufforschung","year":"1971","journal-title":"Zeitschrift Kreislaufforschung"},{"key":"bibr10-030006058401200203","first-page":"399","volume":"11","author":"Merkel W","year":"1976","journal-title":"European Journal of Medicinal Chemistry"},{"key":"bibr11-030006058401200203","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1982.43"},{"key":"bibr12-030006058401200203","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1978.tb00837.x"},{"key":"bibr13-030006058401200203","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1979253331"},{"key":"bibr14-030006058401200203","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2125.1979.tb00925.x","volume":"7","author":"Valette H","year":"1979","journal-title":"British Journal of Clinical Pharmacology"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058401200203","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058401200203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:44:37Z","timestamp":1777459477000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006058401200203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,3]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1984,3]]}},"alternative-id":["10.1177\/030006058401200203"],"URL":"https:\/\/doi.org\/10.1177\/030006058401200203","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,3]]}}}