{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:47:27Z","timestamp":1777726047461,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1984,7,1]],"date-time":"1984-07-01T00:00:00Z","timestamp":457488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1984,7]]},"abstract":"<jats:p>A multicentre, parallel group hospital study was carried out in 190 subjects with insomnia to compare the efficacy, incidence of hangover and the side-effects of loprazolam and nitrazepam. Following 2 nights single-blind phase on placebo, loprazolam (1\u00b70 mg), nitrazepam (5\u00b70 mg) or placebo was administered double-blind for 7 consecutive nights. Visual analogue scales and questions were used to rate efficacy.<\/jats:p>\n                  <jats:p>There was no statistically significant difference between loprazolam and nitrazepam for \u2018ease of getting to sleep\u2019, \u2018restfulness of sleep\u2019 and \u2018depth of sleep\u2019. Like nitrazepam, loprazolam diminished the number of periods of wakefulness and made it \u2018easier to get to sleep again\u2019.<\/jats:p>\n                  <jats:p>Subjective evaluation showed that hangover was not a feature of loprazolam. It did not affect morning alertness and patients thought they had improved balance and co-ordination while on this drug. These findings are in keeping with the evidence of other workers who have shown only minimal psychomotor impairment, if any, with loprazolam (1\u00b70 mg).<\/jats:p>\n                  <jats:p>There was no statistically significant difference between treatments with respect to frequency or incidence of side-effects.<\/jats:p>","DOI":"10.1177\/030006058401200402","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T08:21:02Z","timestamp":1484209262000},"page":"229-237","source":"Crossref","is-referenced-by-count":6,"title":["A Multicentre Hospital Study to Compare the Hypnotic Efficacy of Loprazolam and Nitrazepam"],"prefix":"10.1177","volume":"12","author":[{"given":"C Joan","family":"McAlpine","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine, Royal Alexandra Infirmary, Paisley, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S I","family":"Ankier","sequence":"additional","affiliation":[{"name":"Medical Department, Roussel Laboratories Limited, Wembley Park, Middlesex, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine S C","family":"Elliott","sequence":"additional","affiliation":[{"name":"Late of Department of Geriatric Medicine, Royal Alexandra Infirmary, Paisley, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1984,7,1]]},"reference":[{"key":"bibr1-030006058401200402","first-page":"143","volume":"37","author":"Boyd D H A","year":"1983","journal-title":"British Journal of Clinical Practice"},{"key":"bibr2-030006058401200402","first-page":"307","volume":"37","author":"Beaumont G","year":"1983","journal-title":"British Journal of Clinical Practice"},{"key":"bibr3-030006058401200402","unstructured":"Breimer D D, Jochemson R (1982) Pharmacokinetics of hypnotic benzodiazepines in man. Sleep 1982, 6th European Congress on Sleep Research, Zurich, 89."},{"key":"bibr4-030006058401200402","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/7.2.74"},{"key":"bibr5-030006058401200402","doi-asserted-by":"publisher","DOI":"10.1177\/030006058100900507"},{"key":"bibr6-030006058401200402","first-page":"188","volume":"30","author":"Halstrom C","year":"1983","journal-title":"British Journal of Hospital Medicine"},{"key":"bibr7-030006058401200402","first-page":"53","volume":"240","author":"Johns T G","year":"1979","journal-title":"Archives of International Pharmacodynamics"},{"key":"bibr8-030006058401200402","unstructured":"Mims (1983) September. Section 3B; 98."},{"key":"bibr9-030006058401200402","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)91491-X"},{"key":"bibr10-030006058401200402","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/00004714-198304000-00003","volume":"3","author":"Nicholson A N","year":"1983","journal-title":"Journal of Clinical Psychopharmacology"},{"key":"bibr11-030006058401200402","doi-asserted-by":"publisher","DOI":"10.1007\/BF00426651"},{"key":"bibr12-030006058401200402","unstructured":"Pidgen A W (1983) the pharmacokinetic and pharmacodynamic effects of loprazolam in volunteers. Loprazolam Clinical Workshop. The Medicine Publishing Foundation, Oxford, pp 12."},{"key":"bibr13-030006058401200402","doi-asserted-by":"publisher","DOI":"10.1007\/BF00542354"},{"key":"bibr14-030006058401200402","unstructured":"Swift C G (1983) Pharmacokinetics and pharmacodynamics of loprazolam in the young and elderly. Loprazolam Clinical Workshop. The Medicine Publishing Foundation, Oxford, pp 10."},{"key":"bibr15-030006058401200402","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.47.1.1"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058401200402","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058401200402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:44:44Z","timestamp":1777459484000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006058401200402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,7]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1984,7]]}},"alternative-id":["10.1177\/030006058401200402"],"URL":"https:\/\/doi.org\/10.1177\/030006058401200402","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,7]]}}}