{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:48:01Z","timestamp":1777726081440,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1985,3,1]],"date-time":"1985-03-01T00:00:00Z","timestamp":478483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1985,3]]},"abstract":"<jats:p>Two open, multicentre studies were performed to evaluate the efficacy of 1% tioconazole cream (Trosyd\u00ae, Pfizer) as a once daily treatment for patients with common superficial dermatophyte and yeast infections (t. Pedis, t. versicolor, t. corporis, t. cruris, candidiasis). In Study I, forty-eight patients were treated once daily and forty-nine were treated twice daily. The clinical response rate at the last treatment visit was 96% and 98%, respectively, in the two treatment groups. In Study II, all 107 patients were treated once daily, and the clinical response rate was 95% at the last treatment visit. The mycological cure rates were 85% and 91% in the Study I groups, and 94% in Study II. At the long-term follow-up evaluation (approximately 4 weeks after treatment) favourable clinical responses were seen in 88% of patients in both the Study I groups, and in 94% of patients in Study II. Long-term mycological cures were seen in 80% of patients in both groups of Study I, and in 94% of patients in Study II. Side effects of treatment were generally transient, mild and coincident with disease symptoms, and occurred in six patients (6%) in Study I and in four patients (4%) in Study II. The results of both studies have shown no clinically or statistically significant differences in toleration or efficacy between once daily and twice daily treatment regimens with 1% tioconazole cream for the treatment of superficial dermatophyte infections.<\/jats:p>","DOI":"10.1177\/030006058501300203","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T05:04:28Z","timestamp":1484456668000},"page":"88-95","source":"Crossref","is-referenced-by-count":13,"title":["A Comparative Study of Once versus Twice Daily Treatment of Superficial Dermatophyte and Yeast Infections with Tioconazole (1%) Cream"],"prefix":"10.1177","volume":"13","author":[{"given":"Philip","family":"Kashin","sequence":"first","affiliation":[{"name":"Medical Division, Pfizer International, Inc., 235 East 42nd Street, New York 10017, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique C","family":"Phyfferoen","sequence":"additional","affiliation":[{"name":"Medical Division, Pfizer International, Inc., 235 East 42nd Street, New York 10017, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Medical Division, Pfizer International, Inc., 235 East 42nd Street, New York 10017, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1985,3,1]]},"reference":[{"key":"bibr1-030006058501300203","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.26.5.699"},{"key":"bibr2-030006058501300203","first-page":"23","volume-title":"Gynakologische Rundschau","author":"Henderson J T","year":"1983"},{"key":"bibr3-030006058501300203","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.15.4.597"},{"key":"bibr4-030006058501300203","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.25.4.450"},{"key":"bibr5-030006058501300203","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/6.6.749"},{"key":"bibr6-030006058501300203","first-page":"166","volume-title":"Dermatologica","author":"East M O'Neill","year":"1983"},{"key":"bibr7-030006058501300203","doi-asserted-by":"publisher","DOI":"10.1159\/000249911"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058501300203","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058501300203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:44:58Z","timestamp":1777459498000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006058501300203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1985,3]]}},"alternative-id":["10.1177\/030006058501300203"],"URL":"https:\/\/doi.org\/10.1177\/030006058501300203","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,3]]}}}