{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:48:16Z","timestamp":1777726096425,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1985,5,1]],"date-time":"1985-05-01T00:00:00Z","timestamp":483753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1985,5]]},"abstract":"<jats:p>The pharmacokinetics of amoxycillin in the CSF following intravenous and oral administration at a 150 mg\/kg per day or 250 mg\/kg per day dosage in the treatment of purulent meningitis is described.<\/jats:p>\n                  <jats:p>A significant correlation between meningeal inflammation and CSF levels of amoxycillin were observed, including a correlation between the initial neurological state and the outcome of the Illness.<\/jats:p>\n                  <jats:p>Despite the early introduction of oral therapy and the reduction in dosage following meningeal and pneumococcal meningitis, no treatment failures could be attributed to this therapeutic regime. Such a treatment schedule, moreover, reduces the risk of superinfection in hospital as well as the cost of treatment and aids the comfort to the patient.<\/jats:p>\n                  <jats:p>La pharmacocin\u00e9tique de l'amoxicilline dans le liquide c\u00e9phalo-rachidien suivant des administrations intra-veineuses et orales de 150 mg\/kg\/j ou 250 mg\/kg\/j lors des m\u00e9ningites purulentes est d\u00e9crite.<\/jats:p>\n                  <jats:p>Une corr\u00e9lation significative entre l'inflammation m\u00e9ning\u00e9e et les taux intra-rachidiens d'amoxicilline, de m\u00eame entre l'\u00e9tat neurologique initial et l'issue de la maladie sont observ\u00e9es.<\/jats:p>\n                  <jats:p>En d\u00e9pit de la pr\u00e9cocite\u00e9 du relais oral, et de la r\u00e9duction des posologies lors des m\u00e9ningites \u00e0 m\u00e9ningocoque, et pneumocoque, aucun \u00e9chec ne peut \u00eatre attribu\u00e9 \u00e0 ce protocole th\u00e9rapeutique. Ce protocole efficace r\u00e9duit de plus les risques de surrinfections hospitali\u00e8res et le co\u00fbt du traitement, et augmente le confort du malade.<\/jats:p>","DOI":"10.1177\/030006058501300308","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T13:48:47Z","timestamp":1484142527000},"page":"188-195","source":"Crossref","is-referenced-by-count":1,"title":["Amoxicilline Orale dans les M\u00e9ningites Purulentes de l'Enfant: Relais Pr\u00e9coce et R\u00e9duction de la Posologie"],"prefix":"10.1177","volume":"13","author":[{"given":"L","family":"Tazi-Lakhassi","sequence":"first","affiliation":[{"name":"Service des Maladies Infectieuses, H\u00f4pital d'Enfants, C.H.U. Averroes, Casablanca, Maroc"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Benbachir","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, C.H.U. Averroes, Casablanca, Maroc"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N El","family":"Mdaghri","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, C.H.U. Averroes, Casablanca, Maroc"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Zaghloul","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses, H\u00f4pital d'Enfants, C.H.U. Averroes, Casablanca, Maroc"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1985,5,1]]},"reference":[{"key":"bibr1-030006058501300308","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(66)80076-8"},{"key":"bibr2-030006058501300308","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.16.3.346"},{"key":"bibr3-030006058501300308","first-page":"36","volume":"29","author":"Lacut J Y","year":"1981","journal-title":"Current Therapeutic Research Clinical and Experimental"},{"key":"bibr4-030006058501300308","unstructured":"Lafaix C H (1977) Place de l'amoxicilline en th\u00e9rapeutique anti-infectieuse. Compte rendu de la r\u00e9union des pharmaciens d'h\u00f4pitaux. SNMP, Edit, Neuilly."},{"key":"bibr5-030006058501300308","doi-asserted-by":"publisher","DOI":"10.1159\/000238072"},{"key":"bibr6-030006058501300308","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/129.Supplement_2.S123"},{"key":"bibr7-030006058501300308","doi-asserted-by":"publisher","DOI":"10.1016\/S0399-077X(80)80119-3"},{"key":"bibr8-030006058501300308","volume-title":"Laboratory Methods in Antimicrobial Chemotherapy","author":"Reeves D S","year":"1978"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058501300308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058501300308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:45:04Z","timestamp":1777459504000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006058501300308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,5]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,5]]}},"alternative-id":["10.1177\/030006058501300308"],"URL":"https:\/\/doi.org\/10.1177\/030006058501300308","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,5]]}}}