{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:48:30Z","timestamp":1777726110507,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1985,9,1]],"date-time":"1985-09-01T00:00:00Z","timestamp":494380800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1985,9]]},"abstract":"<jats:p>Eight asthmatics with respiratory intolerance to NSAIDs and two subjects (one asthmatic, one healthy) only sensitive (asthma) to pyrazolone drugs were challenged under single-blind conditions with a new NSAID, carprofen.<\/jats:p>\n                  <jats:p>\n                    No adverse effects were observed in patients sensitive to pyrazolones. Among the other patients, only three developed considerable bronchial obstruction which was rapidly reversed by inhalation of a \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    -stimulant (fenoterol: 2 puffs). Two subjects developed nasal obstruction with rhinorrhoea: in conjunction with bronchoconstriction in one patient and alone in the other.\n                  <\/jats:p>\n                  <jats:p>In conclusion, acute administration of carprofen in patients with respiratory intolerance to NSAIDs, in contrast to most other NSAIDs, never creates a situation of real danger even though in some patients it may considerably increase nasal and bronchial resistance.<\/jats:p>","DOI":"10.1177\/030006058501300509","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T11:39:16Z","timestamp":1484480356000},"page":"294-299","source":"Crossref","is-referenced-by-count":2,"title":["Tolerance of Carprofen in Patients with Asthma Caused by Non-Steroidal Anti-Inflammatory Drugs"],"prefix":"10.1177","volume":"13","author":[{"given":"S","family":"Bianco","sequence":"first","affiliation":[{"name":"Institute of Phthisiology and Respiratory System Diseases, University of Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Robuschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Simone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Vaghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Pasargiklian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1985,9,1]]},"reference":[{"key":"bibr1-030006058501300509","first-page":"129","volume":"5","author":"Bianco S","year":"1977","journal-title":"I.R.C.S.J. Med. Sci."},{"key":"bibr2-030006058501300509","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1981.tb01842.x"},{"key":"bibr3-030006058501300509","unstructured":"Jeunet F (1982) General assessment of \u2018Imadyl\u2019. An overview of preclinical and clinical investigations. (Editiones \u2018Roche\u2019, Basle) p 14."},{"key":"bibr4-030006058501300509","doi-asserted-by":"publisher","DOI":"10.1159\/000193780"},{"key":"bibr5-030006058501300509","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(82)90081-1"},{"key":"bibr6-030006058501300509","first-page":"478","volume":"5","author":"Strub K M","year":"1982","journal-title":"Eur. J. Rheumat. Inflamm"},{"key":"bibr7-030006058501300509","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198325060-00001"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058501300509","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058501300509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:45:07Z","timestamp":1777459507000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006058501300509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,9]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1985,9]]}},"alternative-id":["10.1177\/030006058501300509"],"URL":"https:\/\/doi.org\/10.1177\/030006058501300509","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,9]]}}}