{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:48:45Z","timestamp":1777726125123,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1986,3,1]],"date-time":"1986-03-01T00:00:00Z","timestamp":510019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1986,3]]},"abstract":"<jats:p>One hundred and twenty adult patients with high temperatures (\u226538\u00b0C) brought about by influenza viruses or other conditions were randomly treated with two different antipyretics: a) a 25 mg sodium diclofenac tablet (Novapirina) every 12 hours for 2 consecutive days; b) a 500 mg tablet of acetylsalicylic acid (Aspirin) every 8 hours for 2 consecutive days. Antipyretic action (assessed at 6 hours following the first administration) was found to be equally rapid and consistent in both cases but significantly longer-lasting in the Novapirina-treated group than the Aspirin-treated group (p &lt; 0\u00b701). Mean temperature changes over the 48 hours of observation and the over-all judgement on the antipyretic effect expressed at the end of each day of treatment were similar for both groups and good in all cases.<\/jats:p>\n                  <jats:p>The antiphlogistic-painkilling properties of both drugs were found to be effective in improving the symptomatology accompanying the high temperature during the course of the bout of influenza.<\/jats:p>\n                  <jats:p>The effectiveness\/tolerability ratio was found to be satisfactory for both groups: only one case of gastric intolerance to Novapirina was recorded and five cases of gastric intolerance to Aspirin.<\/jats:p>","DOI":"10.1177\/030006058601400208","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T10:09:46Z","timestamp":1484215786000},"page":"95-100","source":"Crossref","is-referenced-by-count":12,"title":["Diclofenac Sodium versus Acetylsalicylic Acid: A Randomized Study in Febrile Patients"],"prefix":"10.1177","volume":"14","author":[{"given":"R","family":"Bettini","sequence":"first","affiliation":[{"name":"General Practitioner in Varese-district, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Grossi","sequence":"additional","affiliation":[{"name":"General Practitioner in Milan-district, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Rapazzini","sequence":"additional","affiliation":[{"name":"General Practitioner in Varese-district, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Giardina","sequence":"additional","affiliation":[{"name":"General Practitioner in Novara-district, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,3,1]]},"reference":[{"key":"bibr1-030006058601400208","first-page":"421","volume":"2","author":"Kein\u00e4nen-Kiukaannicmi S","year":"1980","journal-title":"Clinical Therapeutics"},{"key":"bibr2-030006058601400208","first-page":"271","volume-title":"\u2018Chronic forms of polyarthritis\u2019","author":"Krupp P","year":"1975"},{"key":"bibr3-030006058601400208","first-page":"646","volume":"105","author":"Krupp P","year":"1975","journal-title":"Schweizerische Medizinische Wochenschrift"},{"issue":"10","key":"bibr4-030006058601400208","first-page":"1317","volume":"22","author":"Kuriyama T","year":"1980","journal-title":"Modern Clinical Medicine"},{"key":"bibr5-030006058601400208","doi-asserted-by":"publisher","DOI":"10.3109\/03009747809097211"},{"key":"bibr6-030006058601400208","doi-asserted-by":"publisher","DOI":"10.1177\/030006058100900508"},{"key":"bibr7-030006058601400208","first-page":"302","volume-title":"\u2018Chronic forms of polyarthritis\u2019","author":"Riess W","year":"1976"},{"key":"bibr8-030006058601400208","doi-asserted-by":"publisher","DOI":"10.3109\/03009747809097212"},{"key":"bibr9-030006058601400208","first-page":"73","volume-title":"\u2018Voltaren \u2014 new findings\u2019","author":"Schubiger B I","year":"1982"},{"key":"bibr10-030006058601400208","unstructured":"Soranzo M L, Salassa B, Bramato C, Gallo V, Baroni L (1980) Azione antipiretica del diclofenac sodico. Gazzetta Medica Italiana 139."},{"key":"bibr11-030006058601400208","first-page":"233","volume-title":"\u2018Temperature regulation and drug action\u2019","author":"Ziel R","year":"1975"},{"key":"bibr12-030006058601400208","first-page":"141","volume-title":"\u2018Brain dysfunction in infantile febrile convulsions","author":"Ziel R","year":"1976"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058601400208","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058601400208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:45:11Z","timestamp":1777459511000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006058601400208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,3]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,3]]}},"alternative-id":["10.1177\/030006058601400208"],"URL":"https:\/\/doi.org\/10.1177\/030006058601400208","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,3]]}}}