{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:48:51Z","timestamp":1777726131112,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1986,5,1]],"date-time":"1986-05-01T00:00:00Z","timestamp":515289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1986,5]]},"abstract":"<jats:p>This study was a double-blind, parallel group comparison of terfenadine (TRF) 60 mg b.i.d. and mequitazine (MQZ) 5 mg b.i.d. for 7 days in the symptomatic treatment of acute pollinosis. The trial took place in the same geographic area and during the same pollen season (May-July 85), to ensure homogeneity of the study population. The fourteen investigators participating in this multicentre trial recruited 141 patients (69 TRF; 72 MQZ) suffering from well-documented pollinosis, mainly hay fever and sometimes allergy to tree pollens. Symptoms (nasal itching, sneezing, rhinorrhoea, obstruction, conjunctivitis) and possible somnolence were rated daily using a 4-point rating-scale of 0 to 3 by the patient on a diary card. Assessment of over-all efficacy and tolerability \u2013 focusing on atropinic side-effects \u2013 was made at the end of the seven-days treatment period by the physician, after reviewing the diary card and questioning the patient.<\/jats:p>\n                  <jats:p>The means score profile of each symptom for the study period was similar with the two treatments. Both had a fast onset of action with the regression of the total symptoms' score being already significant at day 1. Over-all assessment of efficacy at day 7 showed no significant difference between the two treatments. The daily somnolence scores however showed a clear and significant difference between the two drugs: the frequency of moderate to marked somnolence from day 2 to 7 was around 15% with MQZ and around 5% on days 2 to 5 and 0% on days 6 and 7 with TRF, the difference being significant on days 2, 5, 6 and 7. The incidence of blurred vision was 7% with MQZ requiring cessation of therapy in one patient, compared with 0% with TRF (p &lt; 0-06). Side-effects other than somnolence and atropinic effects were reported in two TRF and six MQZ patients. In conclusion terfenadine and mequitazine displayed the same efficacy for symptoms of pollinosis, but terfenadinie was better tolerated.<\/jats:p>","DOI":"10.1177\/030006058601400302","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T18:19:30Z","timestamp":1409854770000},"page":"124-130","source":"Crossref","is-referenced-by-count":4,"title":["A Double-Blind Comparison of Terfenadine and Mequitazine in the               Symptomatic Treatment of Acute Pollinosis"],"prefix":"10.1177","volume":"14","author":[{"given":"L","family":"Hugonot","sequence":"first","affiliation":[{"name":"Professor, Service de M\u00e9decine interne, C.H.U. de Grenoble, B.P. 217 X, 38043                  Grenoble Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Hugonot","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine interne, C.H.U. de Grenoble, B.P. 217 X, 38043 Grenoble                  Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Beaumont","sequence":"additional","affiliation":[{"name":"Merrell Dow France, 45-49, rue de Villiers, B.P. 11-92203 Neuilly S\/Seine,                  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Cahen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Colomby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Dufour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Gardant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Krotenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Mathes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Maurin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Oualid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Rouach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Caperan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Pin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Zambelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,5,1]]},"reference":[{"key":"bibr1-030006058601400302","first-page":"1581","volume":"10","author":"Caille E J","year":"1978","journal-title":"Psychologie M\u00e9dicate"},{"key":"bibr2-030006058601400302","doi-asserted-by":"publisher","DOI":"10.1159\/000250123"},{"key":"bibr3-030006058601400302","first-page":"189","volume":"35","author":"Dry J","year":"1980","journal-title":"Th\u00e9rapie"},{"key":"bibr4-030006058601400302","first-page":"15","volume":"9","author":"Halpern G","year":"1977","journal-title":"Allergie et Immunologie"},{"key":"bibr5-030006058601400302","first-page":"1133","volume":"43","author":"Kalis B","year":"1985","journal-title":"M\u00e9decine et Hygi\u00e8ne"},{"key":"bibr6-030006058601400302","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1978.tb01677.x"},{"key":"bibr7-030006058601400302","first-page":"1173","volume":"32","author":"Leeson G A","year":"1982","journal-title":"Arzneimittel Forschung"},{"key":"bibr8-030006058601400302","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(81)90432-X"},{"issue":"3","key":"bibr9-030006058601400302","first-page":"213","volume":"16","author":"Leophonte P","year":"1984","journal-title":"Allergie et Immunologie"},{"key":"bibr10-030006058601400302","doi-asserted-by":"publisher","DOI":"10.1007\/BF00716383"},{"key":"bibr11-030006058601400302","doi-asserted-by":"publisher","DOI":"10.1007\/BF00542129"},{"key":"bibr12-030006058601400302","first-page":"1171","volume":"32","author":"Rose C","year":"1982","journal-title":"Arzneimittel Forschung"},{"key":"bibr13-030006058601400302","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198529010-00002"},{"key":"bibr14-030006058601400302","unstructured":"Trzeciakowski J P, Levi R (1983) Antihistamines. Allergy principles and                  practices, 2nd, 575, Middleton EJr, Reed C E, Ellis E F, eds. 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