{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:48:59Z","timestamp":1777726139531,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1986,7,1]],"date-time":"1986-07-01T00:00:00Z","timestamp":520560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1986,7]]},"abstract":"<jats:p>Phenotypes of susceptibility to amoxycillin (Amo), ticarcillin (Tic), cephalothin (Ctn) were determined in 1366 isolates of Enterobacteriaceae by disk method and beta-lactamases were identified in 243 strains belonging to different phenotypes of amoxycillin-resistant strains.<\/jats:p>\n                  <jats:p>\n                    Amo\n                    <jats:sup>R<\/jats:sup>\n                    Tic\n                    <jats:sup>R<\/jats:sup>\n                    Ctn\n                    <jats:sup>s<\/jats:sup>\n                    strains (25%) were penicillinase producers and all of them were susceptible to the combination amoxicillin\/clavulanic acid (Amo\/CA) and ticarcillin\/clavulanic acid (Tic\/CA). Amo\n                    <jats:sup>I\/R<\/jats:sup>\n                    Tic\n                    <jats:sup>s<\/jats:sup>\n                    Ctn\n                    <jats:sup>R<\/jats:sup>\n                    strains (12%) were cephalosporinase producers and resistance to Amo\/CA was observed, except for Proteus vulgaris. Amo\n                    <jats:sup>R<\/jats:sup>\n                    Tic\n                    <jats:sup>R<\/jats:sup>\n                    Ctn\n                    <jats:sup>R<\/jats:sup>\n                    strains (18%) often produced two beta-lactamases (penicillinase and cephalosporinase) and they were resistant to Amo\/CA; in this group, susceptibility to Tic\/CA depends on the nature and the amount of the beta-lactamase produced, except for Serratia marcescens for which antibiotic resistance is probably due to other mechanisms. Tic\/CA resistance was mainly found in Serratia marcescens (41%) and Enterobacter cloacae (36%).\n                  <\/jats:p>","DOI":"10.1177\/030006058601400405","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T20:16:19Z","timestamp":1484338579000},"page":"193-199","source":"Crossref","is-referenced-by-count":3,"title":["Resistance to Beta-Lactams in Enterobacteriaceae: Distribution of Phenotypes Related to Beta-Lactamase Production"],"prefix":"10.1177","volume":"14","author":[{"given":"D","family":"Sirot","sequence":"first","affiliation":[{"name":"Service de Bact\u00e9riologie, 28, Place Henri Dunant, 63001 Clermont Ferrand Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Sirot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Saulnier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Joly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Chanal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Cluzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Cluzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,7,1]]},"reference":[{"key":"bibr1-030006058601400405","doi-asserted-by":"publisher","DOI":"10.1007\/BF02014879"},{"key":"bibr2-030006058601400405","doi-asserted-by":"publisher","DOI":"10.1007\/BF02016562"},{"key":"bibr3-030006058601400405","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/9.suppl_C.203"},{"key":"bibr4-030006058601400405","first-page":"745","volume-title":"Current Chemotherapy and Infectious Diseases","author":"Christenson J","year":"1980","edition":"1"},{"key":"bibr5-030006058601400405","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/13.2.121"},{"issue":"5","key":"bibr6-030006058601400405","first-page":"301","volume":"33","author":"Deforges L","year":"1985","journal-title":"Pathologie Biologie"},{"key":"bibr7-030006058601400405","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.25.3.392"},{"key":"bibr8-030006058601400405","unstructured":"Gonzalez-Lama Z, Soria S, Lama A M, Lopez-Orge R H (1983) Isoelectric focusing of beta-lactamases from Klebsiella pneumoniae. In: 13th International Congress of Chemotherapy, Vienna, Part 89."},{"key":"bibr9-030006058601400405","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/146.1.34"},{"key":"bibr10-030006058601400405","volume-title":"B\u00eata-lactamases et expression physiologique de la r\u00e9sistance des bacilles gram n\u00e9gatif aux B\u00eata-lactamines","author":"Guionie M","year":"1981"},{"key":"bibr11-030006058601400405","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/13.1.15"},{"key":"bibr12-030006058601400405","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/6.4.455"},{"key":"bibr13-030006058601400405","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/14.suppl_B.59"},{"key":"bibr14-030006058601400405","unstructured":"King A, Gransden W R, Phillips I (1983) The effect of clavulanic acid on the susceptibility to ticarcillin of Enterobacteriaceae and Pseudomonas aeruginosa that produce chromosomally and plasmid-determined B-lactamases. 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In: 13th International Congress of Chemotherapy, Vienna, Part 22."},{"key":"bibr16-030006058601400405","first-page":"1597","volume":"283","author":"Labia R","year":"1976","journal-title":"Compte Rendu de l'Acad\u00e9mie des Sciences (Paris)"},{"key":"bibr17-030006058601400405","first-page":"295","volume":"130","author":"Labia R","year":"1979","journal-title":"Annales de Microbiologic (Institut Pasteur)"},{"key":"bibr18-030006058601400405","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-88-1-169"},{"key":"bibr19-030006058601400405","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.6.6.791"},{"key":"bibr20-030006058601400405","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.14.5.650"},{"key":"bibr21-030006058601400405","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.1.4.283"},{"key":"bibr22-030006058601400405","unstructured":"Philippon A M, Paul G C, Nevot P A (1980) Synergy of clavulanic acid with penicillins against ampicillin and carbenicillin-resistant Gram-negative organisms, related to their type of beta-lactamase. 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