{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:49:18Z","timestamp":1777726158212,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1987,1,1]],"date-time":"1987-01-01T00:00:00Z","timestamp":536457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:p>Eleven open multicentre studies were conducted to evaluate the efficacy of tioconazole cream 1% as a treatment for diaper rash with or without fungal ( Candida) involvement, or impetigo in neonates and infants. In the dermal candidiasis\/diaper rash group, 320 patients had either tioconazole ( n = 220), a comparative imidazole ( n = 43), or vehicle cream ( n = 57) applied to the affected area twice daily. Twenty-one impetigo patients had only tioconazole cream 1% applied three times daily to lesions. The overall cure rate (patients with both clinical and mycological cure) at the end of treatment for tioconazole treated patients was 78%, for the comparative imidazole group it was 76% and for vehicle cream it was 39%. At the long-term follow-up evaluation approximately 6 weeks after treatment for patients with diaper rash, the overall cure rate was about the same in both tioconazole- and comparative imidazole-treated patients (87% and 90%, respectively), and 14% in patients using vehicle cream. Side-effects were coincident with disease symptoms and consisted primarily of erythema localized to the treatment area; they occurred in 5.4% (13\/241) of the patients who received tioconazole and in 21% (9\/43) of the patients who received comparative imidazole (econazole or miconazole). No side-effects were reported in this open study for the 57 patients who used vehicle cream. The results of these studies show that tioconazole cream 1% is safe and effective for the treatment of neonates and infants with dermal candidiasis, diaper rash and impetigo.<\/jats:p>","DOI":"10.1177\/030006058701500103","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T21:59:23Z","timestamp":1484517563000},"page":"23-31","source":"Crossref","is-referenced-by-count":8,"title":["Comparative and Non-Comparative Studies of the Efficacy and Tolerance of Tioconazole Cream 1% versus Another Imidazole and\/or Placebo in Neonates and Infants with Candidal Diaper Rash and\/or Impetigo"],"prefix":"10.1177","volume":"15","author":[{"given":"D. L.","family":"Gibbs","sequence":"first","affiliation":[{"name":"Medical Division, Pfizer International, 235 East 42nd Street, New York, NY 10017, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Kashin","sequence":"additional","affiliation":[{"name":"Medical Division, Pfizer International, 235 East 42nd Street, New York, NY 10017, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Jevons","sequence":"additional","affiliation":[{"name":"Medical Division, Pfizer International, 235 East 42nd Street, New York, NY 10017, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1987,1,1]]},"reference":[{"key":"bibr1-030006058701500103","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.15.4.597"},{"key":"bibr2-030006058701500103","doi-asserted-by":"publisher","DOI":"10.1159\/000249907"},{"key":"bibr3-030006058701500103","doi-asserted-by":"publisher","DOI":"10.1159\/000249911"},{"key":"bibr4-030006058701500103","doi-asserted-by":"publisher","DOI":"10.1159\/000269570"},{"key":"bibr5-030006058701500103","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5648.23"},{"key":"bibr6-030006058701500103","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1971.04000160050008"},{"key":"bibr7-030006058701500103","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1978.01640130020006"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058701500103","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058701500103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:45:19Z","timestamp":1777459519000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006058701500103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1177\/030006058701500103"],"URL":"https:\/\/doi.org\/10.1177\/030006058701500103","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}