{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:50:23Z","timestamp":1777726223324,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1988,7,1]],"date-time":"1988-07-01T00:00:00Z","timestamp":583718400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1988,7]]},"abstract":"<jats:p>This double-blind, randomized, placebo-controlled study investigated the therapeutic effects of a single dose of doxofylline, a methylxanthine derivative, in 10 patients aged 26\u201379 years. All patients had acute exacerbation of chronic obstructive airways disease partially reversible with salbutamol inhaler. Doxofylline was administered intravenously at a dose of 200 mg over 15 min on two different occasions separated by at least 24 h. Doxofylline increased forced expiratory volume in the first second of expiration compared with baseline as follows: +20% after 2 h ( P&lt;0.01); +31% after 4 h ( P&lt;0.01); and +13% after 6 h (NS). Changes produced by placebo at these times were \u22124.4%, \u221214% and \u22125% (all NS). The average differences between the groups were significant at all observation times. At the end of the observation period eight out of 10 patients given doxofylline and one out of 10 patients given placebo had improved clinically according to the patients' own opinion. Clinical tolerability of doxofylline proved to be good since no signs of local or general side-effects were observed in any of the patients treated.<\/jats:p>","DOI":"10.1177\/030006058801600403","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T23:10:04Z","timestamp":1484089804000},"page":"264-269","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of Intravenously Administered Doxofylline and Placebo for the Treatment of Severe Acute Airways Obstruction"],"prefix":"10.1177","volume":"16","author":[{"given":"A.","family":"Dolcetti","sequence":"first","affiliation":[{"name":"VI Division of Pneumology, Hospital S. Luigi, Orbassano, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Osella","sequence":"additional","affiliation":[{"name":"VI Division of Pneumology, Hospital S. Luigi, Orbassano, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"De Filippis","sequence":"additional","affiliation":[{"name":"VI Division of Pneumology, Hospital S. Luigi, Orbassano, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Carnuccio","sequence":"additional","affiliation":[{"name":"VI Division of Pneumology, Hospital S. Luigi, Orbassano, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Grossi","sequence":"additional","affiliation":[{"name":"VI Division of Pneumology, Hospital S. Luigi, Orbassano, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1988,7,1]]},"reference":[{"key":"bibr1-030006058801600403","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1972133349"},{"key":"bibr2-030006058801600403","unstructured":"US Food and Drug Administration: I. v. dosage guidelines for theophylline products. FDA Drug Bull 4\u20136 February 1980."},{"key":"bibr3-030006058801600403","first-page":"201","volume":"36","author":"Franzone JS","year":"1981","journal-title":"Il Farmaco Ed Sci"},{"key":"bibr4-030006058801600403","unstructured":"Fonzo D, Bucca C, Rolla G, Pharmacological and clinical findings on doxofylline, a new antibronchospastic agent. 8th International Congress of Pharmacology, Tokyo, 19\u201324 July 1981 IV Phar. Tokyo-Ab. 611, 409."},{"key":"bibr5-030006058801600403","first-page":"91","volume":"3","author":"Nosenzo M","year":"1987","journal-title":"Rass Pat Appl Respir"},{"key":"bibr6-030006058801600403","first-page":"95","volume":"3","author":"Panagia P","year":"1987","journal-title":"Rass Pat Appl Respir"},{"key":"bibr7-030006058801600403","first-page":"101","volume":"2","author":"Bucca C","year":"1982","journal-title":"Int J Clin Pharm Res"},{"key":"bibr8-030006058801600403","unstructured":"Braghiroli A, Sacco C, Mora G, Theophylline versus doxofylline effect on sleep architecture. 7th Congress of the European Society of Pneumology, Budapest, 5\u20139 September 1988."},{"key":"bibr9-030006058801600403","unstructured":"Lazzaroni M, Grossi E, Bianchi Porro G: Doxofylline: a new xanthine derivative with low gastric secretagogue activity. 20th Congress of the European Association of Gastroenterologists, Sirmione, 28\u201330 April 1988-Abstract 112, 137."},{"key":"bibr10-030006058801600403","unstructured":"Iodice F, De Michele F, Sena A, Effetti ventilatori ed emogasanalitici della somministrazione acuta della doxofillina in soggetti con BPCO. Dati preliminari sugli effetti emodinamici immediati in soggetti normali. 2nd Italian Conference On Respiratory Medicine, Rome, 3\u20137 May 1988-Abstract, 219."},{"key":"bibr11-030006058801600403","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1986.tb00293.x"},{"key":"bibr12-030006058801600403","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1980.02130180054016"},{"key":"bibr13-030006058801600403","first-page":"1219","volume":"134","author":"Hurley SF","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"bibr14-030006058801600403","doi-asserted-by":"publisher","DOI":"10.1016\/0007-0971(80)90074-1"},{"key":"bibr15-030006058801600403","first-page":"190","volume":"123","author":"Rossing TH","year":"1981","journal-title":"Am Rev Respir Dis"},{"key":"bibr16-030006058801600403","author":"Dolcetti A","journal-title":"Min Pneumol"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058801600403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058801600403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:45:43Z","timestamp":1777459543000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006058801600403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,7]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1988,7]]}},"alternative-id":["10.1177\/030006058801600403"],"URL":"https:\/\/doi.org\/10.1177\/030006058801600403","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,7]]}}}