{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T21:09:59Z","timestamp":1783717799344,"version":"3.55.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1989,1,1]],"date-time":"1989-01-01T00:00:00Z","timestamp":599616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:p>The therapeutic efficacy of 0.8% chlormethiazole, administered as 3\u201310 intravenous infusions each lasting 5\u20136 h on alternate days, was assessed in an uncontrolled study of 16 patients, aged 44\u201382 years, with primary trigeminal neuralgia. Prior to entry into the study, patients showed a high frequency of neuralgic paroxysms (20\u201370 attacks\/day) which were refractory to high dosages (1600\u20132000 mg\/day) of carbamazepine. After treatment with chlormethiazole neuralgic paroxysms no longer occurred in five patients, were considerably reduced in intensity and frequency (\u22645 attacks\/day) in six patients, moderately improved in two patients, slightly improved in one patient and showed no change in two patients. The relatively small number of cases and short post-treatment follow-up period limit the conclusions which can be drawn. These results indicate, however, that infusion with chlormethiazole is effective in the treatment of primary trigeminal neuralgia in patients for whom conventional therapy has been unsuccessful.<\/jats:p>","DOI":"10.1177\/030006058901700113","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T03:22:00Z","timestamp":1484623320000},"page":"87-92","source":"Crossref","is-referenced-by-count":3,"title":["Intravenous Chlormethiazole in the Management of Primary Trigeminal Neuralgia Resistant to Conventional Therapy"],"prefix":"10.1177","volume":"17","author":[{"given":"N.","family":"Zurak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Randic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Poljakovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"V\u00f6glein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1989,1,1]]},"reference":[{"key":"bibr1-030006058901700113","unstructured":"Merskey H: Classification of chronic pain. 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