{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:51:24Z","timestamp":1777726284206,"version":"3.51.4"},"reference-count":89,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1989,5,1]],"date-time":"1989-05-01T00:00:00Z","timestamp":609984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1989,5]]},"abstract":"<jats:p>\n                    The effects on general and bone metabolism of femoral neck fracture patients of 0.25 \u03bcg \u03b1-calcoid given orally twice daily ( n=9) and 25 \u03bcg calcitonin given subcutaneously 30 times ( n=10) in 10 weeks were studied against a control ( n=ll). Bone histology and histomorphometry showed non-age related osteoporosis in 30% and osteomalacia in 22% of the patients studied. Impaired serum vitamin D status was found in 47 \u2013 88% of patients, secondary hyperparathyroidism and increased serum parathyroid hormone in 59% and decreased serum calcitonin levels in 69%. On histology, normal findings and non-age related osteoporosis on histology were associated with low serum levels of 25-hydroxyvitamin D\n                    <jats:sub>3<\/jats:sub>\n                    ,1,25- and 24,25-dihydroxy vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    . Very high serum levels of 1,25-dihydroxyvitamin D\n                    <jats:sub>3<\/jats:sub>\n                    and low levels of 25-hydroxyvitamin D\n                    <jats:sub>3<\/jats:sub>\n                    occurred in fracture patients with osteomalacia. Calcitonin improved calcium balance, reduced osteoporosis and increased the serum 1,25- and 24,25-dihydroxyvitamin D\n                    <jats:sub>3<\/jats:sub>\n                    levels but had no effect on osteomalacia. Vitamin D reduced osteomalacia, slightly increased the serum 1,25-dihydroxyvitamin D\n                    <jats:sub>3<\/jats:sub>\n                    concentration and decreased serum levels of parathyroid hormone. Both treatments gave a similar slight decrease in serum calcitonin concentrations. A mechanism of action for the treatments is suggested.\n                  <\/jats:p>","DOI":"10.1177\/030006058901700305","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T14:39:35Z","timestamp":1484663975000},"page":"226-242","source":"Crossref","is-referenced-by-count":9,"title":["Vitamin D and Calcitonin Treatment in Patients with Femoral Neck Fracture: A Prospective Controlled Clinical Study"],"prefix":"10.1177","volume":"17","author":[{"given":"E.","family":"Harju","sequence":"first","affiliation":[{"name":"Department of Surgery and Clinical Sciences, Gynaecology, University of Tampere, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Punnonen","sequence":"additional","affiliation":[{"name":"Department of Surgery and Clinical Sciences, Gynaecology, University of Tampere, Tampere, 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