{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:21:19Z","timestamp":1777724479497,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1989,9,1]],"date-time":"1989-09-01T00:00:00Z","timestamp":620611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1989,9]]},"abstract":"<jats:p>After 4 weeks of placebo treatment, 76 hypertensive patients were randomly allocated to 6 or 12 mg\/day piretanide, or 2.5 mg\/day bendroflumethiazide for 12 weeks in a double-blind study. Piretanide was given in a slow-release formulation and bendroflumethiazide as a tablet. All three treatments produced a significant reduction in supine and erect systolic and diastolic blood pressures after 2 weeks, and this effect was maintained throughout the study. Normotension (i.e. supine diastolic pressure \u2264 95 mmHg) was achieved in 73% of the patients receiving 12 mg\/day piretanide and in 57% receiving 6 mg\/day piretanide compared with 72% receiving bendroflumethiazide (not significant). Overall, five patients were withdrawn due to increased diuresis: two patients on each dosage of piretanide and one receiving bendroflumethiazide. Three patients receiving 6 mg\/day piretanide were withdrawn due to diastolic blood pressure rising above 120 mmHg. Other side-effects reported were mild and transient. There were no significant changes in serum creatinine, glucose or high-density lipoprotein cholesterol. A small, but non-significant rise in uric acid level was seen in all three groups. Clinically relevant hypokalaemia requiring potassium supplementation occurred in three patients receiving bendroflumethiazide.<\/jats:p>","DOI":"10.1177\/030006058901700504","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T03:42:36Z","timestamp":1484106156000},"page":"426-434","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of Slow-Release Piretanide and Bendroflumethiazide in the Treatment of Mild to Moderate Hypertension"],"prefix":"10.1177","volume":"17","author":[{"given":"J.","family":"Hegbrant","sequence":"first","affiliation":[{"name":"Department of Medicine, H\u00e4ssleholm Hospital, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Skogstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Medicine, \u00d6rebro Medical Centre Hospital, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"M\u00e5nsby","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Svenska Hoechst AB, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1989,9,1]]},"reference":[{"key":"bibr1-030006058901700504","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198529060-00002"},{"key":"bibr2-030006058901700504","doi-asserted-by":"publisher","DOI":"10.1177\/030006058401200203"},{"key":"bibr3-030006058901700504","first-page":"595","volume":"3","author":"Verho M","year":"1984","journal-title":"Pharmatherapeutica"},{"key":"bibr4-030006058901700504","doi-asserted-by":"publisher","DOI":"10.1007\/BF00544079"},{"key":"bibr5-030006058901700504","first-page":"40","volume":"80","author":"H\u00e4ringer EP","year":"1985","journal-title":"Med Klin"},{"key":"bibr6-030006058901700504","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF01733828","volume":"63","author":"Zidek W","year":"1985","journal-title":"Klin Wochenschr"},{"key":"bibr7-030006058901700504","volume-title":"Statistical Methods in Medical Research.","author":"Armitage P","year":"1974"},{"key":"bibr8-030006058901700504","first-page":"385","volume":"12","author":"Verho M","year":"1986","journal-title":"Drugs Exp Clin Res"},{"key":"bibr9-030006058901700504","doi-asserted-by":"publisher","DOI":"10.1185\/03007998309109814"},{"key":"bibr10-030006058901700504","doi-asserted-by":"publisher","DOI":"10.1007\/BF00549586"},{"key":"bibr11-030006058901700504","doi-asserted-by":"publisher","DOI":"10.1177\/030006058501300105"},{"key":"bibr12-030006058901700504","doi-asserted-by":"publisher","DOI":"10.1007\/BF00609755"},{"key":"bibr13-030006058901700504","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1984.tb03631.x"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058901700504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006058901700504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:40:02Z","timestamp":1777459202000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006058901700504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,9]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1989,9]]}},"alternative-id":["10.1177\/030006058901700504"],"URL":"https:\/\/doi.org\/10.1177\/030006058901700504","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,9]]}}}