{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:24:26Z","timestamp":1777724666925,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1991,3,1]],"date-time":"1991-03-01T00:00:00Z","timestamp":667785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1991,3]]},"abstract":"<jats:p>In an open multicentre study, 410 patients presenting with traumatic joint distortions, predominantly involving the ankle, were recruited for treatment with 50 mg diclofenac potassium given orally three times daily for 7 days. Due to various protocol violations, the number of patients eligible for efficacy and tolerability analysis were 340 and 344, respectively. Significant ( P &lt; 0.001) improvement in mobility, swelling, local tenderness, functional impairment and pain intensity occurred after both 3 and 7 days of therapy. Overall efficacy was assessed as excellent\/good in 83% and 87% of cases by the investigator and patient, respectively. Altogether, 66 (19.2%) patients complained of adverse effects, which were generally mild or moderate in severity. Gastrointestinal complaints accounted for around 70% of the reported side-effects. Premature discontinuation of therapy due to poor tolerability was necessary in 15 (4.4%) patients. In conclusion, diclofenac potassium was both effective and well-tolerated when used for the short-term treatment of traumatic joint distortions.<\/jats:p>\n                  <jats:p>Dans cette \u00e9tude ouverte multicentrique, 410 patients souffrant d'entorses, touchant essentiellement la cheville, ont \u00e9t\u00e9 inclus pour traitement par trois comprim\u00e9s \u00e0 50 mg de diclof\u00e9nac potassium par jour pendant 7 jours. Du fait de diff\u00e9rents \u00e9carts au protocole, 340 patients ont pu \u00eatre analys\u00e9s pour l'efficacit\u00e9, et 344 pour la tol\u00e9rance. Une am\u00e9lioration significative ( P &lt; 0,001) a pu \u00eatre observ\u00e9e concernant la mobilit\u00e9, l'oed\u00e8me, la douleur \u00e0 la palpation locale, l'impotence fonctionnelle et l'intensit\u00e9 de la douleur spontan\u00e9e apr\u00e8s 3 et 7 jours de traitement. A l'\u00e9valuation globale, l'efficacit\u00e9 a \u00e9t\u00e9 jug\u00e9e excellente ou bonne par le m\u00e9decin dans 83% des cas, et par le patient dans 87% des cas. Au total, 66 (19,2%) patients ont rapport\u00e9 des effets ind\u00e9sirables, qui \u00e9taient g\u00e9n\u00e9ralement de s\u00e9v\u00e9rit\u00e9 mineure ou mod\u00e9r\u00e9e. Environ 70% des plaintes concernaient le syst\u00e8me digestif. Quinze (4,4%) patients ont d\u00fb interrompre pr\u00e9matur\u00e9ment le traitement pour raison de mauvaise tol\u00e9rance. En conclusion, le diclof\u00e9nac potassium, en administration de courte dur\u00e9e, s'est av\u00e9r\u00e9 efficace et bien tol\u00e9r\u00e9 pour le traitement des entorses.<\/jats:p>","DOI":"10.1177\/030006059101900211","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T23:33:27Z","timestamp":1484091207000},"page":"165-170","source":"Crossref","is-referenced-by-count":5,"title":["Diclofenac Potassium for the Treatment of Traumatic Joint Distortions: An Open Multicentre Study"],"prefix":"10.1177","volume":"19","author":[{"given":"A.","family":"Verstraeten","sequence":"first","affiliation":[{"name":"Medical Department, SA Ciba-Geigy NV, Groot-Bijgaarden, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bakshi","sequence":"additional","affiliation":[{"name":"Medical Department, Ciba-Geigy Ltd, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,3,1]]},"reference":[{"key":"bibr1-030006059101900211","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198835030-00004"},{"key":"bibr2-030006059101900211","first-page":"310","volume":"43","author":"Lasmar NP","year":"1986","journal-title":"Rev Bras Med"},{"key":"bibr3-030006059101900211","first-page":"130","volume":"11","author":"Andrade D","year":"1984","journal-title":"Invest Med Int"},{"key":"bibr4-030006059101900211","doi-asserted-by":"publisher","DOI":"10.1177\/030006059001800205"},{"key":"bibr5-030006059101900211","volume-title":"SPSS\/PC+: Statistical Package for the Social Services\u2013Manual.","author":"Norusis MJ","year":"1988"},{"key":"bibr6-030006059101900211","first-page":"53","volume":"92","author":"Anonymous","year":"1986","journal-title":"Folha Med (Rio de Janiero)"},{"key":"bibr7-030006059101900211","first-page":"61","volume":"99","author":"Editorial","year":"1980","journal-title":"Harefuah"},{"key":"bibr8-030006059101900211","first-page":"709","volume":"46","author":"Bakshi R","year":"1989","journal-title":"Curr Ther Res"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059101900211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059101900211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:40:28Z","timestamp":1777459228000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006059101900211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,3]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,3]]}},"alternative-id":["10.1177\/030006059101900211"],"URL":"https:\/\/doi.org\/10.1177\/030006059101900211","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,3]]}}}