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The insulin dose was further increased to 30 IU\/day and the patient was also treated with 20 mg nafamostat mesylate given intravenously twice daily for 6 days. On completion of nafamostat mesylate treatment serum C3 concentrations were increased but after 17 days they started to decrease again.<\/jats:p>","DOI":"10.1177\/030006059101900408","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T02:52:02Z","timestamp":1484103122000},"page":"348-350","source":"Crossref","is-referenced-by-count":0,"title":["Complement Activation via the Alternative Pathway in a Patient with Insulin-Dependent Diabetes Mellitus"],"prefix":"10.1177","volume":"19","author":[{"given":"S.","family":"Okada","sequence":"first","affiliation":[{"name":"Third Department of Medicine, Okayama University Medical School, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ichiki","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, Okayama University Medical School, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tanokuchi","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, Okayama University Medical School, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ishii","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, Okayama University Medical School, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Hamada","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, Okayama University Medical School, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Medicine, Aioi Municipal Hospital, Aioi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Ota","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, Okayama University Medical School, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,7,1]]},"reference":[{"key":"bibr1-030006059101900408","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198012253032601"},{"key":"bibr2-030006059101900408","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/BF00274796","volume":"30","author":"Okada S","year":"1987","journal-title":"Diabetologia"},{"key":"bibr3-030006059101900408","first-page":"185","volume":"45","author":"Okada S","year":"1991","journal-title":"Acta Med Okayama"},{"key":"bibr4-030006059101900408","doi-asserted-by":"publisher","DOI":"10.1177\/030006059101900309"},{"key":"bibr5-030006059101900408","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.35.203"},{"key":"bibr6-030006059101900408","doi-asserted-by":"publisher","DOI":"10.1007\/BF00429704"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059101900408","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059101900408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:40:34Z","timestamp":1777459234000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006059101900408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1991,7]]}},"alternative-id":["10.1177\/030006059101900408"],"URL":"https:\/\/doi.org\/10.1177\/030006059101900408","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,7]]}}}