{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:25:27Z","timestamp":1777724727478,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1991,9,1]],"date-time":"1991-09-01T00:00:00Z","timestamp":683683200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1991,9]]},"abstract":"<jats:p>\n                    Acute rejection of renal allografts was treated with the monoclonal antibody OKT\n                    <jats:sub>3<\/jats:sub>\n                    given intravenously. A variety of adverse events were observed on days 1 and 2 following treatment with 5 mg\/day OKT\n                    <jats:sub>3<\/jats:sub>\n                    for 10 days including heart failure, pulmonary oedema and hypertension. Continuous monitoring of 19 patients treated with OKT\n                    <jats:sub>3<\/jats:sub>\n                    for acute renal allograft rejection detected a transient increase, lasting 2 h, in systolic and diastolic blood pressures on day 1. A larger increase in systolic and diastolic pressures lasting 11 \u2013 13 h was observed on day 2. Treatment with 5 mg OKT\n                    <jats:sub>3<\/jats:sub>\n                    on day 3 did not significantly increase systolic or diastolic pressure. It is concluded that OKT\n                    <jats:sub>3<\/jats:sub>\n                    can aggravate hypertension and hypertensive emergencies may be encountered during the initial phase of OKT\n                    <jats:sub>3<\/jats:sub>\n                    treatment.\n                  <\/jats:p>","DOI":"10.1177\/030006059101900510","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T09:05:32Z","timestamp":1484211932000},"page":"419-423","source":"Crossref","is-referenced-by-count":3,"title":["Acute Hypertension after Renal Allograft Rejection Therapy with OKT\n                    <sub>3<\/sub>\n                    Monoclonal Antibody"],"prefix":"10.1177","volume":"19","author":[{"given":"C.","family":"Spieker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Zidek","sequence":"additional","affiliation":[{"name":"Medical Clinic of Wilhelms University, Munster, FRG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Barenbrock","sequence":"additional","affiliation":[{"name":"Medical Clinic of Wilhelms University, Munster, FRG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Wieneke","sequence":"additional","affiliation":[{"name":"Medical Clinic of Wilhelms University, Munster, FRG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Buchholz","sequence":"additional","affiliation":[{"name":"Surgical Clinic of Wilhelms University, Munster, FRG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.-H.","family":"Rahn","sequence":"additional","affiliation":[{"name":"Medical Clinic of Wilhelms University, Munster, FRG"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,9,1]]},"reference":[{"key":"bibr1-030006059101900510","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198112000-00018"},{"key":"bibr2-030006059101900510","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198508083130601"},{"key":"bibr3-030006059101900510","first-page":"2748","volume":"17","author":"Flye W","year":"1985","journal-title":"Transplant Proc"},{"key":"bibr4-030006059101900510","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.3.1805"},{"key":"bibr5-030006059101900510","unstructured":"Zlabinger GJ, Steiner G, Klauser R,  Cytokine release and acute phase response after OKT\n                      3\n                      therapy [abstract]. 27th Congress of the European Dialysis and Transplantation Association,Vienna, 5\u20137 September 1990, abstract no. 233."},{"key":"bibr6-030006059101900510","doi-asserted-by":"publisher","DOI":"10.1378\/chest.95.4.817"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059101900510","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059101900510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:40:36Z","timestamp":1777459236000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006059101900510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,9]]},"references-count":6,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1991,9]]}},"alternative-id":["10.1177\/030006059101900510"],"URL":"https:\/\/doi.org\/10.1177\/030006059101900510","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,9]]}}}