{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:25:27Z","timestamp":1777724727355,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1991,11,1]],"date-time":"1991-11-01T00:00:00Z","timestamp":688953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1991,11]]},"abstract":"<jats:p>Azithromycin (total dose 1.5 g) given orally in five or six doses over 5 days was compared with erythromycin and cloxacillin both given orally as 500 mg four times daily for 7 days in two multicentre studies of patients with skin and associated soft-tissue infections. Azithromycin eradicated baseline pathogen(s), mainly Staphylococcus aureus, in 89% compared with in 78%, of erythromycin-treated patients ( P = 0.501) and in 78% compared with in 59% of cloxacillin-treated patients ( P = 0.421). No statistically significant difference in clinical cure was reported between azithromycin (74%) and erythromycin (75%, P = 1.00) and between azithromycin (60%) and cloxacillin (47%, P = 0.301) treatment groups. The side-effects reported for azithromycin were mainly mild or moderate gastrointestinal complaints and there were no major abnormalities in laboratory parameters. It is concluded that azith-romycin was as effective as, but better tolerated than, either erythromycin or cloxacillin and short-course therapy may improve patient compliance.<\/jats:p>","DOI":"10.1177\/030006059101900602","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T03:20:05Z","timestamp":1484536805000},"page":"433-445","source":"Crossref","is-referenced-by-count":35,"title":["Azithromycin, Erythromycin and Cloxacillin in the Treatment of Infections of Skin and Associated Soft Tissues"],"prefix":"10.1177","volume":"19","author":[{"given":"R.","family":"Daniel","sequence":"first","affiliation":[{"name":"Department of Clinical Research, Pfizer Central Research, Sandwich, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"European Azithromycin Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,11,1]]},"reference":[{"key":"bibr1-030006059101900602","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.12.1939"},{"key":"bibr2-030006059101900602","unstructured":"Girard AE, Cinochowski CR, Faiella JA: Effectiveness of azithromycin in eradicating streptococcal pathogens from localized infections [abstract],\n                      6th International Congress on Infectious Diseases, Montreal\n                      , 1990."},{"key":"bibr3-030006059101900602","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.6.1056"},{"key":"bibr4-030006059101900602","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.3.277"},{"key":"bibr5-030006059101900602","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/25.suppl_A.73"},{"key":"bibr6-030006059101900602","doi-asserted-by":"publisher","DOI":"10.1007\/BF01641314"},{"key":"bibr7-030006059101900602","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/25.suppl_A.61"},{"key":"bibr8-030006059101900602","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.295.6602.814"},{"key":"bibr9-030006059101900602","first-page":"266","volume":"10","author":"Cacciatore L","year":"1988","journal-title":"Clin Ther"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059101900602","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059101900602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:40:36Z","timestamp":1777459236000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006059101900602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,11]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1991,11]]}},"alternative-id":["10.1177\/030006059101900602"],"URL":"https:\/\/doi.org\/10.1177\/030006059101900602","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,11]]}}}