{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:27:37Z","timestamp":1777724857931,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1992,2,1]],"date-time":"1992-02-01T00:00:00Z","timestamp":696902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:p>The safety and efficacy of 500 mg O-( \u03b2-hydroxyethyl)rutosides given orally twice daily in the treatment of 97 patients with first-, second-, or third-degree haemorrhoids were investigated in a double-blind, randomized placebo-controlled trial. The rutosides produced a significant ( P &lt; 0.001) improvement in patient-assessed subjective symptoms (pain, bleeding, exudation and pruritus) compared with placebo. There was also a significant ( P &lt; 0.0001) improvement in clinician-assessed subjective and objective signs (bleeding, inflammation and dilatation of the haemorrhoidal plexus) after 2 and 4 weeks' treatment compared with placebo. There were three mild, transient side-effects reported in the active treatment group and no drug-related problems in the pregnancy or delivery were observed. The results suggest that O-( \u03b2-hydroxyethyl)rutosides provide a safe and effective treatment for women with haemorrhoids of pregnancy.<\/jats:p>","DOI":"10.1177\/030006059202000107","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T17:51:23Z","timestamp":1484157083000},"page":"54-60","source":"Crossref","is-referenced-by-count":34,"title":["A Clinical Trial of Hydroxyethylrutosides in the Treatment of Haemorrhoids of Pregnancy"],"prefix":"10.1177","volume":"20","author":[{"given":"H","family":"Wijayanegara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JC","family":"Mose","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Hasan Sadikin Hospital, Bandung, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Achmad","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Gunung Jati Hospital, Cirebon, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Sobarna","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Rajawali Hospital, Bandung, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Permadi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Hasan Sadikin Hospital, Bandung, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,2,1]]},"reference":[{"key":"bibr1-030006059202000107","first-page":"121","volume":"52","author":"Renevey R","year":"1963","journal-title":"Schweiz Rundsch Med Prax"},{"key":"bibr2-030006059202000107","first-page":"391","volume":"5","author":"Wissmer BAL","year":"1963","journal-title":"Curr Ther Res"},{"key":"bibr3-030006059202000107","first-page":"420","volume":"198","author":"Clyne MB","year":"1967","journal-title":"Practitioner"},{"key":"bibr4-030006059202000107","first-page":"378","volume":"201","author":"General Practitioner Research Group","year":"1968","journal-title":"Practitioner"},{"key":"bibr5-030006059202000107","first-page":"45","volume":"10","author":"Sinnatamby CS","year":"1973","journal-title":"Clin Trials J"},{"key":"bibr6-030006059202000107","first-page":"39","volume":"2","author":"Gerdin B","year":"1983","journal-title":"Int J Microcirc Clin Exp"},{"key":"bibr7-030006059202000107","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1989.tb11902.x"},{"key":"bibr8-030006059202000107","doi-asserted-by":"publisher","DOI":"10.1007\/BF00562934"},{"key":"bibr9-030006059202000107","first-page":"253","volume":"10","author":"Bergqvist D","year":"1981","journal-title":"Vasa"},{"key":"bibr10-030006059202000107","doi-asserted-by":"publisher","DOI":"10.1177\/030006057500300308"},{"key":"bibr11-030006059202000107","first-page":"485","volume":"28","author":"Samartzis S","year":"1971","journal-title":"Ther Umsch"},{"key":"bibr12-030006059202000107","first-page":"1273","volume":"90","author":"Schmid W","year":"1972","journal-title":"Fortschr Med"},{"key":"bibr13-030006059202000107","first-page":"60","volume":"20","author":"Wild C","year":"1969","journal-title":"Am J Proctol"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059202000107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059202000107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:40:57Z","timestamp":1777459257000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006059202000107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,2]]}},"alternative-id":["10.1177\/030006059202000107"],"URL":"https:\/\/doi.org\/10.1177\/030006059202000107","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,2]]}}}