{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:27:49Z","timestamp":1777724869739,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1992,4,1]],"date-time":"1992-04-01T00:00:00Z","timestamp":702086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1992,4]]},"abstract":"<jats:p>\n                    The clinical significance of combining local anaesthetics with dextran is controversial. Although a number of investigators have found that dextran can prolong the action of local anaesthetics, others have not been able to demonstrate any significant change in the duration of anaesthesia. A study was carried out to investigate the effect of dextran on the pharmacokinetic behaviour of lignocaine during epidural anaesthesia in 20 adult male patients, who were randomly allocated to two treatment groups: group 1 ( n = 10) was given lignocaine \u2013 dextran; group 2 ( n = 10) was given lignocaine \u2013 saline. The results of the study demonstrated that the addition of dextran to epidural lignocaine significantly slowed systemic absorption of lignocaine as indicated by a smaller absorption rate constant, a reduced peak plasma concentration (C\n                    <jats:sub>max<\/jats:sub>\n                    ), a delayed time to reach Cmax, and a smaller area under the concentration \u2013 time curve. The observed findings suggest that dextran reduces vascular uptake of lignocaine from epidural space and that it may prolong the duration of action. The significance of these findings on systemic toxicity, dosage and onset of action of lignocaine need to be investigated.\n                  <\/jats:p>","DOI":"10.1177\/030006059202000205","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T01:51:14Z","timestamp":1484531474000},"page":"127-135","source":"Crossref","is-referenced-by-count":3,"title":["The Effect of Dextran on the Pharmacokinetics of Lignocaine during Epidural Anaesthesia"],"prefix":"10.1177","volume":"20","author":[{"given":"A","family":"Alkhawajah","sequence":"first","affiliation":[{"name":"Department of Pharmacology, College of Medicine, King Faisal University, Dammam, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Farag","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, College of Medicine, King Faisal University, Dammam, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,4,1]]},"reference":[{"key":"bibr1-030006059202000205","author":"Loder RE","year":"1960","journal-title":"Lancet"},{"key":"bibr2-030006059202000205","doi-asserted-by":"publisher","DOI":"10.1136\/thx.17.4.375"},{"key":"bibr3-030006059202000205","first-page":"808","volume":"19","author":"Loder RE","year":"1964","journal-title":"Geriatrics"},{"key":"bibr4-030006059202000205","author":"Chinn MA","year":"1967","journal-title":"Lancet"},{"key":"bibr5-030006059202000205","first-page":"221","volume":"16","author":"Nolte H","year":"1967","journal-title":"Anaesthesist"},{"key":"bibr6-030006059202000205","first-page":"182","volume":"26","author":"Mayer RA","year":"1968","journal-title":"J Oral Surg"},{"key":"bibr7-030006059202000205","first-page":"2","volume":"4","author":"Rosenblatt RM","year":"1979","journal-title":"Reg Anaesth"},{"key":"bibr8-030006059202000205","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-197511000-00025"},{"key":"bibr9-030006059202000205","first-page":"6","volume":"3","author":"Bridenbaugh LD","year":"1978","journal-title":"Reg Anaesth"},{"key":"bibr10-030006059202000205","unstructured":"Kingsnorth AN, Wijesinha SS, Grixti CJ Evaluation of dextran with local anaesthesia for shortstay inguinal herniorrhaphy.\n                      Ann R Coll Surg Engl\n                      1979; 61: 456\u2013458."},{"key":"bibr11-030006059202000205","first-page":"207","volume":"68","author":"Armstrong DN","year":"1986","journal-title":"Ann R Coll Surg Engl"},{"key":"bibr12-030006059202000205","first-page":"3","volume":"5","author":"Rosenblatt RM","year":"1980","journal-title":"Reg Anaesth"},{"key":"bibr13-030006059202000205","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600630232"},{"key":"bibr14-030006059202000205","doi-asserted-by":"publisher","DOI":"10.1016\/0169-2607(85)90085-9"},{"key":"bibr15-030006059202000205","doi-asserted-by":"publisher","DOI":"10.2307\/2683122"},{"key":"bibr16-030006059202000205","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1978.tb02174.x"},{"key":"bibr17-030006059202000205","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198005000-00004"},{"key":"bibr18-030006059202000205","first-page":"243","volume":"64","author":"Simpson PJ","year":"1982","journal-title":"Ann R Coll Surg Engl"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059202000205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059202000205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:40:59Z","timestamp":1777459259000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006059202000205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,4]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,4]]}},"alternative-id":["10.1177\/030006059202000205"],"URL":"https:\/\/doi.org\/10.1177\/030006059202000205","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,4]]}}}