{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:28:11Z","timestamp":1777724891449,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1992,6,1]],"date-time":"1992-06-01T00:00:00Z","timestamp":707356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1992,6]]},"abstract":"<jats:p>Of 34 patients with primary myelodysplastic syndrome (MDS), 26 (76.5%) were found to have chromosome defects using an improved bone marrow culture method and high-resolution G-banding technique induced by actinomycin D. The frequency of abnormalities varied among the subtypes: 1\/2 in refractory anaemia with ringed sideroblasts; 18\/24 in refractory anaemia; 5\/6 in refractory anaemia with excess of blasts (RAEB); and 2\/2 in refractory anaemia with excess of blasts in transformation. The most frequent abnormalities, either single, double or complex defects, were \u22125\/5q-, \u22127, +8 and +21; 16q-\/16p-, +19 and \u2212X were also common. The percentage of aneuploid cells, in particular hypodiploid cells, was increased. The abnormalities were detected more frequently in complex aberrations associated with RAEB and RAEB in transformation. The presence of \u22125\/5q- as a sole aberration was associated with longer mean survival time (&gt;18 months) but multiple (more than two) chromosomal abnormalities were associated with a poorer prognosis and a mean survival time of only 7.5 months. Chromosome follow-up studies indicated that patients with \u22127, +8, +21, \u2212X and complex defects, increased hypodiploid cells and karyotpic evolution were likely to have a high risk of transformation to leukaemia or to a more severe subtype of MDS with a short overall mean survival time. These defects, mostly of the deleted type, are assumed to play a specific role in the pathogenesis of myelodysplasia. Repeated chromosomal analyses during the clinical course convey more accurate prognostic criteria for patients.<\/jats:p>","DOI":"10.1177\/030006059202000307","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T21:58:18Z","timestamp":1484690298000},"page":"254-266","source":"Crossref","is-referenced-by-count":3,"title":["Cytogenetic Analysis of Bone Marrow from Patients with Primary Myelodysplastic Syndrome"],"prefix":"10.1177","volume":"20","author":[{"given":"H K","family":"Wu","sequence":"first","affiliation":[{"name":"Laboratory of Haematological Research, Henan Medical University, Zheng-zhou, Peoples' Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Central Clinical Laboratory, Faculty of Medicine, University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y R","family":"Xi","sequence":"additional","affiliation":[{"name":"Laboratory of Haematological Research, Henan Medical University, Zheng-zhou, Peoples' Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y T","family":"Wang","sequence":"additional","affiliation":[{"name":"Cytogenic Laboratory, Institute of Family Planning of Henan Province, Zheng-zhou, Peoples' Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S L","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Haematological Research, Henan Medical University, Zheng-zhou, Peoples' Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D B","family":"Zhou","sequence":"additional","affiliation":[{"name":"Laboratory of Haematological Research, Henan Medical University, Zheng-zhou, Peoples' Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,6,1]]},"reference":[{"key":"bibr1-030006059202000307","doi-asserted-by":"publisher","DOI":"10.1007\/BF00320305"},{"key":"bibr2-030006059202000307","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1600-0609.1986.tb00854.x","volume":"45","author":"Tricot G","year":"1986","journal-title":"Scand J Haematol [Suppl]"},{"key":"bibr3-030006059202000307","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1982.tb08475.x"},{"key":"bibr4-030006059202000307","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90101-F"},{"key":"bibr5-030006059202000307","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1988.tb00207.x"},{"key":"bibr6-030006059202000307","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V67.6.1721.1721"},{"key":"bibr7-030006059202000307","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1985.tb07381.x"},{"key":"bibr8-030006059202000307","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041190314"},{"key":"bibr9-030006059202000307","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198107163050304"},{"key":"bibr10-030006059202000307","first-page":"1","volume":"21","author":"International System for Human Cytogenetic Nomenclature","year":"1985","journal-title":"Birth Defects"},{"key":"bibr11-030006059202000307","first-page":"224","volume":"7","author":"Bing-Zhong S","year":"1982","journal-title":"J PLA Med"},{"key":"bibr12-030006059202000307","first-page":"13","volume":"14","author":"Bing-Zhong S","year":"1985","journal-title":"New Sanshi J Med Pharmacol"},{"key":"bibr13-030006059202000307","first-page":"533","volume":"56","author":"Foucar K","year":"1988","journal-title":"Cancer"},{"key":"bibr14-030006059202000307","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V73.1.248.248"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059202000307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059202000307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:41:03Z","timestamp":1777459263000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006059202000307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,6]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,6]]}},"alternative-id":["10.1177\/030006059202000307"],"URL":"https:\/\/doi.org\/10.1177\/030006059202000307","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,6]]}}}