{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:55:45Z","timestamp":1791330945243,"version":"4.3.1"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1992,8,1]],"date-time":"1992-08-01T00:00:00Z","timestamp":712627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1992,8]]},"abstract":"<jats:p>The effects of topically applied 1% sodium hyaluronate as an alternative treatment to surgery for tympanic membrane perforations was studied. In an open study, the inclusion criteria were increased by accepting patients previously treated by surgery or with placebo and, compared with a previous study, the frequency at which sodium hyaluronate was applied was reduced. Reduction in the size of the perforation was detected in 12\/16 (75.0%) patients, six (37.5%) of whom showed complete tympanic healing, and in the remaining four (25.0%) there was no healing. The average percentage reduction in the perforation area was 80.5%. The two factors altered in this trial, i.e. inclusion criteria and frequency of administration of treatment, had little influence on the degree of membrane healing.<\/jats:p>","DOI":"10.1177\/030006059202000406","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T08:29:26Z","timestamp":1498811366000},"page":"353-359","source":"Crossref","is-referenced-by-count":9,"title":["Effects of Sodium Hyaluronate on Tympanic Membrane Perforations"],"prefix":"10.1177","volume":"20","author":[{"given":"M P Rivas","family":"Lacarte","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Viladecans Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Casasin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Viladecans Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Alonso","sequence":"additional","affiliation":[{"name":"Department of Statistics, Viladecans Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1992,8,1]]},"reference":[{"key":"bibr1-030006059202000406","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100107984"},{"key":"bibr2-030006059202000406","doi-asserted-by":"publisher","DOI":"10.3109\/00016488709102845"},{"key":"bibr3-030006059202000406","unstructured":"Soderberg O, Laurent C, Anniko M, Hyaluronan versus rice paper: a clinical study on the healing of persistent tympanic membrane perforations. XIV World Congress of Otorhinolaryngology, Madrid, 10\u201315 September 1989."},{"key":"bibr4-030006059202000406","doi-asserted-by":"publisher","DOI":"10.1159\/000276182"},{"key":"bibr5-030006059202000406","doi-asserted-by":"publisher","DOI":"10.3109\/00016489009122523"},{"key":"bibr6-030006059202000406","doi-asserted-by":"publisher","DOI":"10.1007\/BF00173662"},{"key":"bibr7-030006059202000406","doi-asserted-by":"publisher","DOI":"10.1002\/bip.1968.360060603"},{"key":"bibr8-030006059202000406","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109857"},{"key":"bibr9-030006059202000406","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(80)90294-6"},{"key":"bibr10-030006059202000406","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(85)80153-X"},{"key":"bibr11-030006059202000406","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(86)80021-7"},{"key":"bibr12-030006059202000406","doi-asserted-by":"publisher","DOI":"10.3109\/00016488809097008"},{"key":"bibr13-030006059202000406","doi-asserted-by":"publisher","DOI":"10.3109\/00016488709102846"},{"key":"bibr14-030006059202000406","first-page":"229","volume":"5","author":"Rivas MP","year":"1989","journal-title":"ORL-DIPS International"},{"key":"bibr15-030006059202000406","doi-asserted-by":"publisher","DOI":"10.3109\/00016488709102840"},{"key":"bibr16-030006059202000406","volume":"12","author":"Casasin T","year":"1990","journal-title":"Pharm Weekbl [Sci]"},{"key":"bibr17-030006059202000406","doi-asserted-by":"crossref","unstructured":"Laurent C, Hellstrom S, Fellenius E: Hyaluronan improves the healing of experimental membrane perforations. Arch Otolaryngol Head Neck Surg 1988; 1435\u20131441.","DOI":"10.1001\/archotol.1988.01860240085029"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059202000406","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059202000406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:41:07Z","timestamp":1777459267000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006059202000406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,8]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,8]]}},"alternative-id":["10.1177\/030006059202000406"],"URL":"https:\/\/doi.org\/10.1177\/030006059202000406","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,8]]}}}