{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:28:39Z","timestamp":1777724919780,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1992,9,1]],"date-time":"1992-09-01T00:00:00Z","timestamp":715305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:p>Vivida\u00ae when used orally has been previously shown to be effective in treating degenerated skin of women. In the present study, 30 women with moderate to severe sund-amaged facial skin applied Vivida\u00ae cream twice daily for 120 days on one side of the face and placebo to the other. Vivida\u00ae was significantly ( P &lt; 0.001) more effective than placebo in improving wrinkles. The effects of Vivida\u00ae cream on mottles and telangiectasis were also significantly ( P &lt; 0.01) greater than those of placebo. Scanner measurement showed that epidermal thickness increased from 0.13 mm to 0.29 mm and dermal thickness from 0.91 mm to 1.29 mm on the Vivida\u00ae-treated side; only minimal changes were observed on the placbeo-treated side. The elasticity index increased from about 50% to 69% on the Vivida\u00ae-treated side and from 49% to 50% on the placebo-treated side.<\/jats:p>\n                  <jats:p>Oral verabreichte Vivida\u00ae zeigte sich fr\u00fcher wirksam in der Behandlung der degenerierten Haut von Frauen. In der vorliegenden Studie trugen 30 Frauen mit mittelschweren bis schweren Sonnensch\u00e4den der Gesichtshaut zweimal t\u00e4glich \u00fcber 120 Tage Vivida\u00ae Creme bzw. Plazebo auf beide Gesichtsh\u00e4lften auf. Vivida\u00ae verbesserte Hautfalten signifikant wirksamer als Plazebo ( P &lt; 0.001). Die Wirkung von Vivida\u00ae auf Flecke und Telangiektasen war auch im Vergleich mit Plazebo signifikant st\u00e4rker ( P &lt; 0.01). Ultraschallmessung ergab eine Zunahme der epidermischen Dicke von 0.13 mm auf 0.29 mm und der dermischen Dicke von 0.91 auf 1.29 mm auf der mit Vivida\u00ae-behandelten Gesichtsh\u00e4lfte; nur minimale Ver\u00e4nderungen wurden auf der plazebo-behandelten H\u00e4lfte beobachtet. Der Elastizit\u00e4ts-index stieg von ca. 50% auf 69% auf der Vivida\u00ae-behandelten H\u00e4lfte und von 49% auf 50% auf der plazebo-behandelten H\u00e4lfte auf.<\/jats:p>","DOI":"10.1177\/030006059202000503","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T16:10:28Z","timestamp":1484064628000},"page":"381-391","source":"Crossref","is-referenced-by-count":2,"title":["The Effect of Vivida\u00ae Cream as Compared with Placebo Cream in the Treatment of Sun-Damaged or Age-Damaged Facial Skin"],"prefix":"10.1177","volume":"20","author":[{"given":"A","family":"Lassus","sequence":"first","affiliation":[{"name":"Helsinki Reasearch Centre, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Eskelinen","sequence":"additional","affiliation":[{"name":"Helsinki Reasearch Centre, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Santalahti","sequence":"additional","affiliation":[{"name":"Helsinki Reasearch Centre, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,9,1]]},"reference":[{"key":"bibr1-030006059202000503","first-page":"199","volume-title":"Advances in Biology of Skin","volume":"6","author":"Sams VM","year":"1965"},{"key":"bibr2-030006059202000503","unstructured":"Schwartz W Morphology and differentiation of connective tissue fibers. In: Connective Tissue (Turnbridge RE ed.). Springfield: Charles C Thomas, 1957; pp 144\u2013156."},{"key":"bibr3-030006059202000503","doi-asserted-by":"publisher","DOI":"10.1084\/jem.88.5.555"},{"key":"bibr4-030006059202000503","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1978.0107"},{"key":"bibr5-030006059202000503","doi-asserted-by":"publisher","DOI":"10.1177\/030006059202000201"},{"key":"bibr6-030006059202000503","doi-asserted-by":"publisher","DOI":"10.1177\/030006059202000304"},{"key":"bibr7-030006059202000503","first-page":"43","volume":"3","author":"Serup J","year":"1987","journal-title":"Bioeng Skin"},{"key":"bibr8-030006059202000503","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1985.tb02848.x"},{"key":"bibr9-030006059202000503","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1984.tb14149.x"},{"key":"bibr10-030006059202000503","doi-asserted-by":"publisher","DOI":"10.3109\/03008208408992779"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059202000503","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059202000503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:41:08Z","timestamp":1777459268000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006059202000503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992,9]]}},"alternative-id":["10.1177\/030006059202000503"],"URL":"https:\/\/doi.org\/10.1177\/030006059202000503","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,9]]}}}