{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:30:00Z","timestamp":1777725000797,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1993,7,1]],"date-time":"1993-07-01T00:00:00Z","timestamp":741484800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:p>A total of 221 cases of deliberate acute overdose with fluvoxamine reported to the Paris Poison Centre, and 78 cases collected by the International Drug Safety Department of Duphar BV were analysed. Other agents, mainly benzodiazepines, neuroleptics, other antidepressants and alcohol, were also taken in 77% of the cases. The acute toxicity that could be attributed to fluvoxamine alone was rarely severe. The symptoms observed were always benign when the dose of fluvoxamine was below 1000 mg and included drowsiness, tremor, nausea, vomiting, abdominal pain, bradycardia and\/or anticholinergic effects (dry mouth, mydriasis, sinus tachycardia, urinary retention). Seizures occurred in a few cases after high doses (generally &gt; 1500 mg). Cardiotoxicity was not a serious problem; sinus bradycardia was noted with doses of less than 1000 mg, but was always moderate and required no treatment. Conduction abnormalities were rare.<\/jats:p>","DOI":"10.1177\/030006059302100405","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:07:20Z","timestamp":1484611640000},"page":"197-208","source":"Crossref","is-referenced-by-count":36,"title":["Acute Fluvoxamine Poisoning"],"prefix":"10.1177","volume":"21","author":[{"given":"R","family":"Garnier","sequence":"first","affiliation":[{"name":"Paris Poisons Centre, University of Paris VII, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Azoyan","sequence":"additional","affiliation":[{"name":"Paris Poisons Centre, University of Paris VII, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Chataigner","sequence":"additional","affiliation":[{"name":"Paris Poisons Centre, University of Paris VII, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Taroulet","sequence":"additional","affiliation":[{"name":"intensive Care Unit, Fernand Widal Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Dellattre","sequence":"additional","affiliation":[{"name":"Laboratoires Duphar & Co., Villeurbanne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M-L","family":"Efthymiou","sequence":"additional","affiliation":[{"name":"Paris Poisons Centre, University of Paris VII, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1993,7,1]]},"reference":[{"key":"bibr1-030006059302100405","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198632040-00002"},{"key":"bibr2-030006059302100405","first-page":"197","volume":"263","author":"Wouters W","year":"1983","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"bibr3-030006059302100405","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6639.1774"},{"key":"bibr4-030006059302100405","doi-asserted-by":"publisher","DOI":"10.1007\/BF03259852"},{"key":"bibr5-030006059302100405","first-page":"398","volume":"12","author":"Lam KS","year":"1988","journal-title":"Gastroenterol Clin Biol"},{"key":"bibr6-030006059302100405","first-page":"6","volume":"17","author":"Tebbs VM","year":"1987","journal-title":"Geriatr Med"},{"key":"bibr7-030006059302100405","doi-asserted-by":"publisher","DOI":"10.1007\/BF03188743"},{"key":"bibr8-030006059302100405","volume-title":"Toxicologie Clinique","author":"Bismuth C","year":"1987","edition":"4"},{"key":"bibr9-030006059302100405","volume-title":"Medical Toxicology New","author":"Ellenhorn MJ","year":"1988"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059302100405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059302100405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:41:19Z","timestamp":1777459279000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006059302100405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,7]]}},"alternative-id":["10.1177\/030006059302100405"],"URL":"https:\/\/doi.org\/10.1177\/030006059302100405","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7]]}}}