{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:30:32Z","timestamp":1777725032576,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1994,3,1]],"date-time":"1994-03-01T00:00:00Z","timestamp":762480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1994,3]]},"abstract":"<jats:p>\n                    Hepatic reticuloendothelial function may be diminished in patients with primary biliary cirrhosis. Endotoxin concentrations in peripheral blood and in the superior mesenteric vein were measured, by the \u03b2-glucan sensitive, factor-free, endotoxin-specific limulus assay, in patients with primary biliary cirrhosis and liver cirrhosis (non-PBC cirrhosis). Endotoxaemia was detected in the peripheral blood of seven out of nine patients (78%) with asymptomatic primary biliary cirrhosis, but in only two out of thirteen patients (15%) with non-PBC cirrhosis. The endotoxin level was significantly higher in the earlier stages of primary biliary cirrhosis than in the later stages (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05). The endotoxin level in superior mesenteric vein blood was significantly lower in patients with primary biliary cirrhosis than in patients with non-PBC cirrhosis. Peripheral endotoxaemia in patients with primary biliary cirrhosis may be due to the diminished capacity of the hepatic reticuloendothelial system, for phagocytosis of endotoxin.\n                  <\/jats:p>","DOI":"10.1177\/030006059402200205","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T19:55:22Z","timestamp":1498852522000},"page":"95-99","source":"Crossref","is-referenced-by-count":13,"title":["A Study of Endotoxaemia in Patients with Primary Biliary Cirrhosis"],"prefix":"10.1177","volume":"22","author":[{"given":"Y","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Tokyo Metropolitan Police Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Sezai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tokyo Metropolitan Police Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Sakurabayashi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tokyo Metropolitan Police Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Hirano","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tokyo Metropolitan Police Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Kamisaka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tokyo Metropolitan Police Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Oka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tokyo Metropolitan Police Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109212"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.2957\/kanzo.31.1315"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600817"},{"key":"e_1_2_1_5_2","first-page":"656","article-title":"Diagnostic criteria of primary biliary cirrhosis","volume":"33","author":"Ota Y","year":"1992","unstructured":"Ota Y: Diagnostic criteria of primary biliary cirrhosis. Acta Hepatol Jap 1992; 33: 656\u2013657 (in Japanese).","journal-title":"Acta Hepatol Jap"},{"key":"e_1_2_1_6_2","first-page":"1257","article-title":"Primary biliary cirrhosis","volume":"60","author":"Scheuer PJ","year":"1967","unstructured":"Scheuer PJ: Primary biliary cirrhosis. Proc R Soc Med 1967; 60: 1257\u20131260.","journal-title":"Proc R Soc Med"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(85)90273-6"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)91108-7"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.1976.12097199"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840080207"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(88)80005-9"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059402200205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059402200205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:41:24Z","timestamp":1777459284000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006059402200205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,3]]}},"alternative-id":["10.1177\/030006059402200205"],"URL":"https:\/\/doi.org\/10.1177\/030006059402200205","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,3]]}}}