{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:31:09Z","timestamp":1777725069910,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1994,7,1]],"date-time":"1994-07-01T00:00:00Z","timestamp":773020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:p>In an open study 55 patients presenting with acute gonorrhoea were given 4.8 mega units procaine penicillin G, intramuscularly, and oral probenecid (1 g) plus one 375-mg tablet clavulanate-potentiated amoxycillin orally. Before this treatment, 53 patients (96.4%) had presented with a purulent discharge, and dysuria was present in 47 patients (85.5%). The presence of Neisseria gonorrhoeae was confirmed by bacterial culture in 54 patients (98.2%). The majority of pathogens (92.5%) were penicillin resistant. On day 3 after treatment, dysuria was absent in 53 patients (96.4%) and there was no discharge in 40 cases (72.7%). N. gonorrhoeae was eradicated in 53 patients (96.4%). Two further patients were bacteriologically cured, but were suffering from post-gonococcal urethritis. The patients in whom discharge was still apparent were further assessed on day 7; discharge was resolved or resolving in all but one patient. There was one treatment failure. No adverse reactions were reported.<\/jats:p>","DOI":"10.1177\/030006059402200405","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T00:10:15Z","timestamp":1484525415000},"page":"236-243","source":"Crossref","is-referenced-by-count":0,"title":["An Open Study of Procaine Penicillin G, Clavulanate-Potentiated Amoxycillin and Probenecid in the Treatment of Acute Gonorrhoea"],"prefix":"10.1177","volume":"22","author":[{"given":"P D","family":"Ekwere","sequence":"first","affiliation":[{"name":"Urology Unit, University Department of Surgery, College of Medical Sciences, University of Calabar, Calabar, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,7,1]]},"reference":[{"key":"bibr1-030006059402200405","volume-title":"Neisseria gonorrhoeae","author":"Osoba AO","year":"1981"},{"key":"bibr2-030006059402200405","first-page":"694","volume":"60","author":"Osoba AO","year":"1983","journal-title":"East Afr Med J"},{"key":"bibr3-030006059402200405","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1136\/jmg-2024-110251","volume":"62","author":"Lim KB","year":"1986","journal-title":"Genitourin Med"},{"key":"bibr4-030006059402200405","first-page":"169","volume":"14","author":"Osoba AO","year":"1985","journal-title":"Afr J Med Sci"},{"key":"bibr5-030006059402200405","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199039020-00008"},{"key":"bibr6-030006059402200405","unstructured":"D'Costa LJ, Ndinya-Achola JO, Haase D, Treatment of PPNG with 4 regimens involving Augmentin with or without probenecid and penicillin plus probenecid with or without a small dose of Augmentin. Afr J Sex Transm Dis 1986; February: 21\u201322."},{"key":"bibr7-030006059402200405","unstructured":"Stokes EJ, Ridgeway TD Clinical Bacteriology, Vol. 5. Edward Arnold, 1980; pp. 200\u2013254."},{"key":"bibr8-030006059402200405","unstructured":"National Committee for Clinical Laboratory Standards Performance (NCCLS). Performance standards for antimicrobial disk susceptibility tests. 4th edn Approved standard NCCLS M2-A4, Vol. 10, No. 7. Villanova, Pennsylvania: NCCLS, April 1991."},{"key":"bibr9-030006059402200405","unstructured":"Osoba AO, Ogunbanjo BO, Adeyemi-Doro FAB, Single dose therapy of gonorrhoea with Augmentin plus probenecid. Afr J Sex Trans Dis 1986; February: 11\u201313."},{"key":"bibr10-030006059402200405","first-page":"29","volume":"60","author":"Latif AS","year":"1984","journal-title":"Br J Verier Dis"},{"key":"bibr11-030006059402200405","unstructured":"Osoba AO, Ogunbanjo BO, Oyejide CO, Efficacy of Augmentin in the treatment of gonorrhoea in Ibadan. Proceedings of the 3rd African Regional Conference on Sexually Transmitted Diseases, Nairobi, Kenya, March 16\u201319, 1983: 53\u201358."},{"key":"bibr12-030006059402200405","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)92806-9"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059402200405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059402200405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:41:29Z","timestamp":1777459289000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006059402200405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,7]]}},"alternative-id":["10.1177\/030006059402200405"],"URL":"https:\/\/doi.org\/10.1177\/030006059402200405","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7]]}}}