{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:31:08Z","timestamp":1777725068050,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1994,9,1]],"date-time":"1994-09-01T00:00:00Z","timestamp":778377600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1994,9]]},"abstract":"<jats:p>\n                    Neutrophils accumulated in the lung are thought to play a key role in the pathogenesis of adult respiratory distress syndrome and interstitial pneumonia following bone-marrow transplantation. The effects of gabexate mesilate on several aspects of human neutrophil function have been investigated. Gabexate mesilate significantly decreased both the generation of reactive oxygen species (O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    , H\n                    <jats:sub>2<\/jats:sub>\n                    0\n                    <jats:sub>2<\/jats:sub>\n                    , OH\u00b7) by neutrophils and neutrophil chemotaxis. In contrast, the drug did not affect the levels of reactive oxygen species generated by a cell-free reactive-oxygen-species generating system. Intracellular calcium concentrations in neutrophils stimulated by f-Met-Leu-Phe were decreased in the presence of gabexate mesilate. These data suggest that the reduction in reactive-oxygen-species production and neutrophil chemotaxis by gabexate mesilate may contribute to the effectiveness of the drug in adult respiratory distress syndrome and interstitial pneumonia after bone-marrow transplantation. The suppression of the increase in intracellular calcium concentration may at least be responsible for the inhibition of these neutrophil functions by gabexate mesilate.\n                  <\/jats:p>","DOI":"10.1177\/030006059402200501","type":"journal-article","created":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T00:51:44Z","timestamp":1484700704000},"page":"245-254","source":"Crossref","is-referenced-by-count":10,"title":["Inhibitory Effect of Gabexate Mesilate on Human Neutrophil Function"],"prefix":"10.1177","volume":"22","author":[{"given":"K","family":"Mikawa","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Kobe University School of Medicine, Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Akamatsu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kansai Medical University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Kobe University School of Medicine, Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Nishina","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Kobe University School of Medicine, Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Obara","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Kobe University School of Medicine, Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Niwa","sequence":"additional","affiliation":[{"name":"Niwa Institute for Immunology, Kochi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,9,1]]},"reference":[{"key":"bibr1-030006059402200501","unstructured":"Saitoh Y Review of clinical results with gabexate mesilate (Foy) in Japan. 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