{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:31:43Z","timestamp":1777725103729,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p>\n                    Recent reports indicate that nadifloxacin is an effective therapy for acne vulgaris and has a mechanism of action similar to that of the tetracyclines which act directly as antioxidants against infiltrated neutrophils. The effects of nadifioxacin on neutrophil functions, including the generation of reactive oxygen species, chemotaxis and phagocytosis were investigated. Nadifloxacin reduced the numbers of superoxide radical anions (O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) and hydroxyl radicals (OH\u00b7) generated by neutrophils. The drug did not, however, significantly inhibit neutrophil chemotaxis and phagocytosis nor did it decrease the levels generated in a cell-free, xanthine\u2013xanthine oxidase system. These results indicate that the clinical effectiveness of nadifloxacin may be partly due to its inhibitory action on the generation of O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    and OH\u00b7 by neutrophils leading to a reduction in oxidative tissue injury.\n                  <\/jats:p>","DOI":"10.1177\/030006059502300103","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T19:48:36Z","timestamp":1484077716000},"page":"19-26","source":"Crossref","is-referenced-by-count":14,"title":["Effect of Nadifloxacin on Neutrophil Functions"],"prefix":"10.1177","volume":"23","author":[{"given":"H","family":"Akamatsu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Kansai Medical University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kansai 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