{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:41:10Z","timestamp":1791895270581,"version":"4.3.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p>Forty-five patients with pancreatic steatorrhoea (27 with calcified pancreatitis, 13 with non-calcified pancreatitis, two with pancreaticoduodenectomy, one with total pancreatectomy, and two with pancreatic cancer) were divided into four groups and given the following medication for 2 to 4 weeks: 4 to 6 g\/day of sodium bicarbonate (group I); 9 g\/day of high-lipase pancreatin (lipase, 56 600 U\/g, F\u00e9d\u00e9ration Internationale Pharmaceutique (FIP); group II); 12 to 24 tablets or 9.0 g of commercial pancreatic enzyme preparations (group III); or 50 mg of omeprazole (group IV). Faecal fat excretion was evaluated before and after drug administration. Faecal fat excretion was reduced by 2.9 g (range, 1.7 to 5.0 g) in group I; 8.8 g (range, 2.9 to 39.9 g) in group II; 10.8 g (range, 2.3 to 21.8 g) in group III; and 4.3 g (range, 3.6 to 5.6 g) in group IV. The pancreatic digestive enzyme preparation was more effective than sodium bicarbonate and agents that raise the pH of the upper small intestine (such as proton-pump inhibitors) in reducing faecal fat excretion. The results indicate that all of the preparations used are effective against mild pancreatic steatorrhoea. If the condition is more advanced, however, a massive dosage of pancreatic digestive enzyme and possibly the combined use of an agent to raise the pH of the upper small intestine are likely to be effective.<\/jats:p>","DOI":"10.1177\/030006059502300105","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T19:48:36Z","timestamp":1484077716000},"page":"37-47","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Pancreatic Digestive Enzymes, Sodium Bicarbonate, and a Proton Pump Inhibitor on Steatorrhoea Caused by Pancreatic Diseases"],"prefix":"10.1177","volume":"23","author":[{"given":"T","family":"Nakamura","sequence":"first","affiliation":[{"name":"The Third Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki-shi, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Takebe","sequence":"additional","affiliation":[{"name":"The Third Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki-shi, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Kudoh","sequence":"additional","affiliation":[{"name":"The Third Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki-shi, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ishii","sequence":"additional","affiliation":[{"name":"The Third Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki-shi, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Imamura","sequence":"additional","affiliation":[{"name":"The Third Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki-shi, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"The Third Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki-shi, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Kasai","sequence":"additional","affiliation":[{"name":"The Third Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki-shi, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Tandoh","sequence":"additional","affiliation":[{"name":"The Third Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki-shi, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Yamada","sequence":"additional","affiliation":[{"name":"The Third Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki-shi, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Arai","sequence":"additional","affiliation":[{"name":"The Third Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki-shi, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Terada","sequence":"additional","affiliation":[{"name":"The Third Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki-shi, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"MacHida","sequence":"additional","affiliation":[{"name":"The Third Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki-shi, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1995,1,1]]},"reference":[{"key":"bibr1-030006059502300105","doi-asserted-by":"publisher","DOI":"10.1007\/BF02777379"},{"key":"bibr2-030006059502300105","first-page":"42","volume":"11","author":"Nakamura T","year":"1988","journal-title":"Digestion Absorption"},{"key":"bibr3-030006059502300105","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)90121-X"},{"key":"bibr4-030006059502300105","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-4-549"},{"key":"bibr5-030006059502300105","doi-asserted-by":"publisher","DOI":"10.1007\/BF02233507"},{"key":"bibr6-030006059502300105","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(70)90122-8"},{"key":"bibr7-030006059502300105","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-198908000-00016"},{"key":"bibr8-030006059502300105","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197706092962304"},{"key":"bibr9-030006059502300105","first-page":"403","volume":"8","author":"Bommelaer G","year":"1984","journal-title":"Gastroenterol Clin Biol"},{"key":"bibr10-030006059502300105","doi-asserted-by":"publisher","DOI":"10.1007\/BF01489321"},{"key":"bibr11-030006059502300105","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296725"},{"key":"bibr12-030006059502300105","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/33.11.2281"},{"key":"bibr13-030006059502300105","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197710202971603"},{"key":"bibr14-030006059502300105","doi-asserted-by":"publisher","DOI":"10.1016\/1056-8727(93)90017-S"},{"key":"bibr15-030006059502300105","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)83187-4"},{"key":"bibr16-030006059502300105","doi-asserted-by":"publisher","DOI":"10.1177\/030006059202000603"},{"key":"bibr17-030006059502300105","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197304192881603"},{"key":"bibr18-030006059502300105","first-page":"526","volume":"82","author":"Lembcke B","year":"1987","journal-title":"Am J Gastroenterol"},{"key":"bibr19-030006059502300105","doi-asserted-by":"publisher","DOI":"10.1007\/BF01300253"},{"key":"bibr20-030006059502300105","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199409000-00007"},{"key":"bibr21-030006059502300105","first-page":"1632","volume":"42","author":"Nakamura T","year":"1984","journal-title":"Nihon Rinsho"},{"key":"bibr22-030006059502300105","first-page":"261","volume":"116","author":"Heiser WD","year":"1965","journal-title":"Bull, Johns Hopkins Hosp"},{"key":"bibr23-030006059502300105","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(79)90278-6"},{"key":"bibr24-030006059502300105","first-page":"27","volume":"84","author":"Bai JC","year":"1989","journal-title":"Am J Gastroenterol"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059502300105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059502300105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:41:33Z","timestamp":1777459293000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006059502300105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1177\/030006059502300105"],"URL":"https:\/\/doi.org\/10.1177\/030006059502300105","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}