{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:34:24Z","timestamp":1777725264330,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1996,5,1]],"date-time":"1996-05-01T00:00:00Z","timestamp":830908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1996,5]]},"abstract":"<jats:p>\n                    A total of 30 patients (27 males and 3 females) with a mean age of 62.6 \u00b1 3.9 years, suffering from chronic obstructive pulmonary disease were recruited into this open study to evaluate the clinical efficacy and the safety of a short course of treatment with 100 mg acebrophylline, twice daily for 14 days. To assess the effectiveness of the drug, symptoms and signs, such as cough intensity and frequency, auscultatory pattern, dyspnoea, cyanosis, difficulty of expectoration, sputum quantity, appearance and density, were evaluated at baseline and after 1, 3, 5, 7,10 and 14 days of therapy. In addition the rheological properties of the bronchial mucus (viscosity and spinnability) were measured and respiratory function tests were performed before and after treatment. There was a progressive improvement of all evaluated symptoms and signs, resulting in improvement of the auscultatory pattern, as well as dyspnoea. This was accompanied by improvement or normalization of the respiratory function indices, which showed statistically significant differences ( P &lt; 0.01) between the baseline and the endpoint values, apart from total lung capacity. Blood-gas analysis demonstrated a significant increase of PaO\n                    <jats:sub>2<\/jats:sub>\n                    and a significant decrease of PaCO\n                    <jats:sub>2<\/jats:sub>\n                    values at the end of the treatment period (both P &lt; 0.01). In general, acebrophylline was well tolerated. No clinically relevant or significant changes in any of the routine laboratory parameters were found on comparing the values obtained before and after treatment. Only three patients complained of epigastric pain, but this was not so severe or long-lasting as to require the discontinuation of the treatment.\n                  <\/jats:p>","DOI":"10.1177\/030006059602400311","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T16:22:56Z","timestamp":1498839776000},"page":"302-310","source":"Crossref","is-referenced-by-count":4,"title":["Effects of a Short Course of Treatment with Acebrophylline on the Mucus Rheological Characteristics and Respiratory Function Parameters in Patients Suffering from Chronic Obstructive Pulmonary Disease"],"prefix":"10.1177","volume":"24","author":[{"given":"G","family":"Agliati","sequence":"first","affiliation":[{"name":"Vaprio d'Adda Hospital, Medical Department, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,5,1]]},"reference":[{"key":"bibr1-030006059602400311","first-page":"117","author":"Campana G","year":"1986","journal-title":"G Ital Ric Clin Terap"},{"key":"bibr2-030006059602400311","unstructured":"Blasi A, Olivieri D: Secrezioni bronchiali ed aspetti fisiopatologici dell'ipersecrezione. II Convegno di Aggiornamento in Pneumologia. Palermo, May 12, 1975."},{"key":"bibr3-030006059602400311","doi-asserted-by":"publisher","DOI":"10.1378\/chest.72.3.341"},{"key":"bibr4-030006059602400311","first-page":"35","volume":"51","author":"Cogo R","year":"1986","journal-title":"Hosp Manage"},{"key":"bibr5-030006059602400311","volume-title":"Patologia delle Vie Aeree","author":"Bonsignore G","year":"1980"},{"key":"bibr6-030006059602400311","unstructured":"Bashmakov YK, Bryuscina TS: The phospholipids of pulmonary surfactant metabolic predecessors of SRS-A. Congress of the European Academy of Allergology and Clinical Immunology, Berlin (West), 17\u201322 September, 1989; p 9."},{"issue":"4","key":"bibr7-030006059602400311","first-page":"525","volume":"6","author":"Grassi C","year":"1984","journal-title":"Med Torac"},{"key":"bibr8-030006059602400311","first-page":"17","volume":"1","author":"Blasi A","year":"1989","journal-title":"CNM Ed Sci"},{"key":"bibr9-030006059602400311","first-page":"475","volume":"121","author":"Cadel S","year":"1982","journal-title":"Boll Chim Farm"},{"key":"bibr10-030006059602400311","first-page":"248","volume":"69","author":"Ericsson CH","year":"1986","journal-title":"Eur J Respir Dis"},{"key":"bibr11-030006059602400311","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1982.tb01641.x"},{"key":"bibr12-030006059602400311","first-page":"98","volume":"61","author":"Matthys H","year":"1980","journal-title":"Eur J Respir Dis"},{"key":"bibr13-030006059602400311","first-page":"453","volume":"11","author":"Barthelemy F","year":"1985","journal-title":"Acta Therapeutica"},{"issue":"6","key":"bibr14-030006059602400311","first-page":"733","volume":"7","author":"Primbs K","year":"1985","journal-title":"Clin Ther"},{"issue":"1338","key":"bibr15-030006059602400311","first-page":"54","volume":"36","author":"Jauregui W","year":"1987","journal-title":"Orient Med"},{"issue":"1336","key":"bibr16-030006059602400311","first-page":"29","volume":"36","author":"Jauregui W","year":"1987","journal-title":"Orient Med"},{"key":"bibr17-030006059602400311","first-page":"435","volume":"22","author":"Weber H","year":"1985","journal-title":"Clin Trials J"},{"key":"bibr18-030006059602400311","first-page":"77","volume":"6","author":"Milvio C","year":"1985","journal-title":"G Ital Ric Clin Terap"},{"key":"bibr19-030006059602400311","first-page":"133","volume":"171","author":"Florez Tascon FJ","year":"1987","journal-title":"Semana Med"},{"key":"bibr20-030006059602400311","first-page":"200","volume":"171","author":"Leon JV","year":"1987","journal-title":"Semana Med"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059602400311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059602400311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:41:54Z","timestamp":1777459314000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006059602400311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,5]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,5]]}},"alternative-id":["10.1177\/030006059602400311"],"URL":"https:\/\/doi.org\/10.1177\/030006059602400311","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,5]]}}}