{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:09:26Z","timestamp":1784300966320,"version":"3.55.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1997,11,1]],"date-time":"1997-11-01T00:00:00Z","timestamp":878342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:p>Rheumatoid arthritis is a chronic progressive disease causing substantial morbidity and mortality for which current treatments are largely unsatisfactory. Over the past 20 years we have developed a novel therapeutic approach based on the intra-articular administration of rifamycin. The published studies on rifamycin therapy of rheumatoid arthritis and other chronic arthritic disorders, mainly from our group, are reviewed. Our results indicate that intra-articular rifamycin is effective against active synovitis and can profitably be combined with any basic therapy with slow-acting antirheumatic drugs. There is good evidence that the development of new erosions can be prevented or delayed by this treatment and that the balance between side-effects (mainly local pain) and antiarthritic activity is very favourable in the long term. Our observations have led us to hypothesize a possible systemic effect of rifamycin injected multilocally in peripheral joints; we believe that the available data deserve further investigation by independent researchers.<\/jats:p>","DOI":"10.1177\/030006059702500601","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T05:50:52Z","timestamp":1484632252000},"page":"307-317","source":"Crossref","is-referenced-by-count":19,"title":["Twenty Years of Experience with Intra-Articular Rifamycin for Chronic Arthritides"],"prefix":"10.1177","volume":"25","author":[{"given":"J","family":"Caruso","sequence":"first","affiliation":[{"name":"Rheumatology Unit, \u2018L. 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