{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:36:00Z","timestamp":1777725360602,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1997,11,1]],"date-time":"1997-11-01T00:00:00Z","timestamp":878342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:p>The efficacy and tolerability of sertraline in 422 out-patients with major depression (DSM-III-R) was evaluated in an open multicentre 8-month study. Patients received sertraline 50 mg\/day; if there was insufficient response at week 4, the dose was increased to 100 mg\/day. After 8 weeks, 68.6% of patients had responded (\u2265 50% reduction in Montgomery \u00c5sberg depression rating scale and clinical global impression scale scores of two or less (improvement of illness) and three or less (severity of illness); of patients receiving continuation treatment, 87.9% maintained at least a partial response at the final visit. The clinical response to the 50 mg\/day dose was maintained throughout the acute treatment in 64% of patients. In all, 23% of the patients had mild or moderate drug-related gastrointestinal disturbances, which generally disappeared after 2 weeks. Only 8% of the patients withdrew because of side-effects. Just over half of the patients were taking other psychotropic drugs. Nevertheless the results of this open study are consistent with those of controlled studies in which sertraline was effective and well tolerated, in acute and continuation treatment for major depression, at 50 mg\/day in most patients.<\/jats:p>","DOI":"10.1177\/030006059702500604","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T05:50:52Z","timestamp":1484632252000},"page":"340-353","source":"Crossref","is-referenced-by-count":3,"title":["An Open Study of Sertraline in Acute and Continuation Treatment of Depressed Out-Patients"],"prefix":"10.1177","volume":"25","author":[{"given":"B","family":"Van Houdenhove","sequence":"first","affiliation":[{"name":"University Hospital, Catholic University of Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Onghena","sequence":"additional","affiliation":[{"name":"Faculty of Psychology and Education, Catholic University of Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Flows","sequence":"additional","affiliation":[{"name":"Notre Dame Clinic, Tournai, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Janssen","sequence":"additional","affiliation":[{"name":"Sint-Annendael, Diest, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AR","family":"De Nayer","sequence":"additional","affiliation":[{"name":"St Theresa's Hospital, Montignies-sur-Sambre, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Boxus","sequence":"additional","affiliation":[{"name":"Private Practice, Waremme, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Iancu","sequence":"additional","affiliation":[{"name":"Private Practice, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,11,1]]},"reference":[{"key":"bibr1-030006059702500604","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(89)90043-8"},{"key":"bibr2-030006059702500604","first-page":"14","volume":"54","author":"Preskorn SH","year":"1993","journal-title":"J Clin Psychiatry"},{"key":"bibr3-030006059702500604","first-page":"46","volume":"49","author":"Doogan DP","year":"1988","journal-title":"J Clin Psychiatry"},{"key":"bibr4-030006059702500604","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199112002-00007"},{"key":"bibr5-030006059702500604","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199210002-00006"},{"key":"bibr6-030006059702500604","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199510030-00001"},{"key":"bibr7-030006059702500604","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(95)00178-8"},{"key":"bibr8-030006059702500604","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1995.03950160039008"},{"key":"bibr9-030006059702500604","doi-asserted-by":"publisher","DOI":"10.1016\/0924-977X(95)90402-Y"},{"key":"bibr10-030006059702500604","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.160.2.217"},{"key":"bibr11-030006059702500604","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199112002-00006"},{"key":"bibr12-030006059702500604","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1996.01830090023004"},{"key":"bibr13-030006059702500604","volume-title":"A double-blind, placebo-controlled study of sertraline in the treatment of outpatients with seasonal affective disorder","author":"Moscovitch A"},{"key":"bibr14-030006059702500604","unstructured":"Katzelnick DJ, Greist JH, Jefferson JW, Sertraline in social phobia: a pilot study. Presented at the XIXth CINP, Washington DC, June 1994."},{"key":"bibr15-030006059702500604","first-page":"41","volume":"32","author":"Yonkers KA","year":"1996","journal-title":"Psychopharmacol Bull"},{"key":"bibr16-030006059702500604","doi-asserted-by":"publisher","DOI":"10.1002\/hup.470100505"},{"key":"bibr17-030006059702500604","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","edition":"3"},{"key":"bibr18-030006059702500604","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"bibr19-030006059702500604","volume-title":"ECDEU Assessment Manual for Psychopharmacology.","author":"Guy W","year":"338"},{"key":"bibr20-030006059702500604","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"bibr21-030006059702500604","unstructured":"SAS Institute Inc: Statistical Analysis System, version 6.08 [Computer program]. Cary, NC: SAS Institute Inc, 1989."},{"key":"bibr22-030006059702500604","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199206005-00001"},{"key":"bibr23-030006059702500604","unstructured":"Fontaine R, The efficacy and safety of sertraline versus imipramine in outpatients with major depression: a six-month double-blind, parallel, multicenter study. Poster presented at the 9th World Congress of Psychiatry, Rio de Janeiro, Brazil 1993; 6\u201312 June."},{"key":"bibr24-030006059702500604","unstructured":"Malt V: Practical aspects of long-term treatment. Presented at VIIth Congress of the European College of Neuropsychopharmacology (ECNP), Jerusalem 1994; 16\u201321 October."},{"key":"bibr25-030006059702500604","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199244040-00007"},{"key":"bibr26-030006059702500604","first-page":"229","volume":"56","author":"Bennie EH","year":"1995","journal-title":"J Clin Psychiatry"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059702500604","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059702500604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:42:10Z","timestamp":1777459330000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006059702500604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1997,11]]}},"alternative-id":["10.1177\/030006059702500604"],"URL":"https:\/\/doi.org\/10.1177\/030006059702500604","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11]]}}}