{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:36:19Z","timestamp":1777725379108,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:p>\n                    The efficacy of switching from one type of H\n                    <jats:sub>2<\/jats:sub>\n                    -receptor antagonist (H\n                    <jats:sub>2<\/jats:sub>\n                    -blocker) to another, in the treatment of H\n                    <jats:sub>2<\/jats:sub>\n                    -blocker-resistant ulcers was investigated using H\n                    <jats:sub>2<\/jats:sub>\n                    -blockers with five-membered rings (five-membered-ring agents) \u2013 such as cimetidine, ranitidine and famotidine \u2013 and an H\n                    <jats:sub>2<\/jats:sub>\n                    -blocker with a six-membered ring, roxatidine. By switching from a five-membered-ring agent to roxatidine in the treatment of five-membered-ring resistant ulcers (study I), gastric ulcers were healed in nine of 19 patients (47%) and duodenal ulcers were healed in eight of nine patients (89%). By switching from roxatidine to one of the five-membered-ring agents in the treatment of roxatidine-resistant ulcers (study II), gastric ulcer was healed in six of 15 patients (40%), and duodenal ulcer was healed in 4 of 10 patients (40%). Particularry in the case of duodenal ulcers, the switch to treatment with roxatidine, which has a different chemical structure from the five-membered-ring agents, may be useful in the treatment of five-membered-ring-resistant ulcers.\n                  <\/jats:p>","DOI":"10.1177\/030006059802600103","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T11:16:32Z","timestamp":1484478992000},"page":"25-36","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Changing the Type of H\n                    <sub>2<\/sub>\n                    -Blocker in the Treatment of H\n                    <sub>2<\/sub>\n                    -Blocker-Resistant Ulcers: Comparison of Roxatidine Acetate Hydrochloride and other H\n                    <sub>2<\/sub>\n                    -Blockers"],"prefix":"10.1177","volume":"26","author":[{"given":"K","family":"Yasutake","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hyogo Medical Center for Adults, Akashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nishiwaki Municipal Hospital, Nishiwaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Mizokami","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kakogawa National Hospital, Kakogawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kobe National Hospital, Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Shinko Kakogawa Hospital, Kakogawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hyogo Prefectual Hospital, Kakogawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Yokoya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hiroshima Mitsubishi Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Irie","sequence":"additional","affiliation":[{"name":"Center for Digestive Disease, Kobe Kaisei Hospital Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1998,1,1]]},"reference":[{"key":"bibr1-030006059802600103","unstructured":"Kaneko E, Ooi S Histamine H\n                      2\n                      -receptor antagonist resistant ulcers. In: Common Disease Series No. 7 \u2013 Peptic Ulcer (Matsuo Y ed). 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In: Refractory Ulcer (Aoki T, Sato N, Nakazawa S eds). Tokyo: Kyowaki-kakutsushin, 1990; pp 57\u201363."},{"key":"bibr11-030006059802600103","unstructured":"Okada M, Yao T Intractable ulcers. In: Common Disease Series No. 7 \u2013 Peptic Ulcer (Matsuo Y ed). Tokyo: Nankodo, 1988; pp 142\u2013150."},{"key":"bibr12-030006059802600103","unstructured":"Ishikawa M, Shigemoto M, Yokoyama I Pathophysiology and treatment of H\n                      2\n                      -blocker resistant gastric ulcers. In: Refractory Ulcer (Aoki T, Sato N, Nakazawa S eds). 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