{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:36:21Z","timestamp":1777725381700,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1998,3]]},"abstract":"<jats:p>Changes in the levels of transforming growth factor-\u03b1 (TGF-\u03b1) in gastric mucosa during ulcer healing were studied in 24 patients with endoscopically confirmed duodenal ulcers, treated either with ranitidine (300 mg daily, at night) or with sucralfate (2 g twice daily). Endoscopic biopsies were taken from the gastric fundus and from the ulcer margin at baseline and after 7 \u2013 10 days of treatment. TGF-\u03b1 levels were determined by radioimmunoassay in paired samples from 22 patients (fundal) and 18 patients (duodenal). There were no significant changes in TGF-\u03b1 levels in the fundus of the whole group or of either treatment group. At the ulcer site, however, there was a significant increase in TGF-\u03b1 levels in the whole group (from 16.4 to 33 pg\/mg protein (medians); P &lt; 0.005), and an increasing trend was seen in both treatment groups but was statistically significant only in the group treated with sucralfate ( P &lt; 0.03).<\/jats:p>","DOI":"10.1177\/030006059802600204","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T07:45:41Z","timestamp":1484293541000},"page":"82-86","source":"Crossref","is-referenced-by-count":5,"title":["Changes in Mucosal Levels of Transforming Growth Factor-\u03b1 from the Oxyntic Region and Ulcer Site during Duodenal Ulcer Healing with Ranitidine or Sucralfate"],"prefix":"10.1177","volume":"26","author":[{"given":"JA","family":"Louw","sequence":"first","affiliation":[{"name":"Gastrointestinal Clinic and Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IM","family":"Modlin","sequence":"additional","affiliation":[{"name":"Gastrointestinal Surgical Pathobiology Research Unit, Yale University and West Haven Veterans' Administration Medical Center, Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Tang","sequence":"additional","affiliation":[{"name":"Gastrointestinal Surgical Pathobiology Research Unit, Yale University and West Haven Veterans' Administration Medical Center, Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GO","family":"Young","sequence":"additional","affiliation":[{"name":"Gastrointestinal Clinic and Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Lucke","sequence":"additional","affiliation":[{"name":"Gastrointestinal Clinic and Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IN","family":"Marks","sequence":"additional","affiliation":[{"name":"Gastrointestinal Clinic and Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1998,3,1]]},"reference":[{"key":"bibr1-030006059802600204","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(88)80351-2"},{"key":"bibr2-030006059802600204","first-page":"203","volume-title":"Mechanisms of Peptic Ulcer Healing","author":"Boyd EJS","year":"1990"},{"key":"bibr3-030006059802600204","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199110000-00006"},{"key":"bibr4-030006059802600204","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114223"},{"key":"bibr5-030006059802600204","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91703-7"},{"key":"bibr6-030006059802600204","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1097\/00004836-199507000-00008","volume":"21","author":"Tsuji S","year":"1995","journal-title":"J Clin Gastroenterol"},{"key":"bibr7-030006059802600204","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018865918932"},{"key":"bibr8-030006059802600204","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.11.3844"},{"key":"bibr9-030006059802600204","doi-asserted-by":"publisher","DOI":"10.1136\/gut.16.11.887"},{"key":"bibr10-030006059802600204","doi-asserted-by":"publisher","DOI":"10.3109\/00365529209095999"},{"key":"bibr11-030006059802600204","doi-asserted-by":"crossref","first-page":"A175","DOI":"10.1016\/0016-5085(92)90123-G","volume":"102","author":"Tarnawski A","year":"1992","journal-title":"Gastroenterology"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059802600204","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006059802600204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:42:13Z","timestamp":1777459333000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006059802600204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,3]]}},"alternative-id":["10.1177\/030006059802600204"],"URL":"https:\/\/doi.org\/10.1177\/030006059802600204","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,3]]}}}