{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:37:00Z","timestamp":1777725420737,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1998,12,1]],"date-time":"1998-12-01T00:00:00Z","timestamp":912470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[1998,12]]},"abstract":"<jats:p>This 28-day, double-blind, randomized study in 256 patients compared the efficacy and safety of mizolastine 10 mg daily with placebo in patients with seasonal allergic rhinoconjunctivitis. All four nasal symptoms (itch, rhinorrhoea, sneezing, obstruction) and three ocular symptoms (itch, tears, redness) were rated by investigators using both a 0 \u2212 3 and a 0 \u2212 9 rating scale. Compared with the placebo group total, nasal and ocular scores were all significantly lower in the mizolastine-treated patients at day 14 of the study ( P = 0.0002 \u2212 0.0009, using the 0 \u2212 9 scale) and relief was maintained throughout the 4-week study duration. Patient diary total scores showed that mizolastine was effective from the first day of treatment. The 0 \u2212 9 scale appears to be more sensitive than the 0 \u2212 3 scale for rating symptoms of seasonal allergic rhinitis.<\/jats:p>\n                  <jats:p>En el ensayo cl\u00ednico aleatorizado, a doble ciego, controlado con placebo, de 28 d\u00edas de duraci\u00f3n y con una muestra de 256 pacientes se compar\u00f3 la eficacia y seguridad de 10 mg de mizolastina en pacientes con rinoconjuntivitis al\u00e9rgica estacional. En total los investigadores evaluaron cuatro s\u00edntomas nasales (picor, rinorrea, estornudo, obstrucci\u00f3n) y tres s\u00edntomas oculares (picor, lagrimeo, eritema). Los resultados se clasificaron utilizando una escala de 0 \u2212 3 y otra de 0 \u2212 9. Las puntuaciones nasales y oculares obtenidas el d\u00eda 14 del estudio en los pacientes tratados con mizolastina fueron significantemente menores comparadas con aquellas observadas en el grupo placebo (P = 0.0002 \u2212 0.0009 utilizando la escala de 0 \u2212 9) y el alivio se mantuvo durante las cuatro semanas de duraci\u00f3n del estudio. Las puntuaciones cotidianas (evaluaci\u00f3n del paciente) mostraron que la mizolastina es efectiva desde el primer d\u00eda de tratamiento. La escala de 0 \u2212 9 result\u00f3 ser m\u00e1s sensible para la evaluaci\u00f3n de s\u00edntomas de rinitis al\u00e9rgica estacional que la escala de 0 \u2212 3.<\/jats:p>","DOI":"10.1177\/030006059802600603","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T12:43:53Z","timestamp":1484052233000},"page":"292-303","source":"Crossref","is-referenced-by-count":10,"title":["Rapid and Sustained Efficacy of Mizolastine 10 mg Once Daily in Seasonal Allergic Rhinitis"],"prefix":"10.1177","volume":"26","author":[{"given":"M","family":"Stern","sequence":"first","affiliation":[{"name":"Asthma and Allergy Research Unit, Leicester General Hospital, Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Blondin-Ertzbischoff","sequence":"additional","affiliation":[{"name":"Synth\u00e9labo Recherche, 31 Avenue P. 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