{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:00:58Z","timestamp":1777917658178,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aim of the study<\/jats:title>\n                    <jats:p>Validation of the sentinel node (SN) technique in breast cancer by means of lymphoscintigraphy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      From December 1996 to January 1999 102 T\n                      <jats:sub>1<\/jats:sub>\n                      -T\n                      <jats:sub>2<\/jats:sub>\n                      breast carcinoma cases were recruited in Turin.\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-human serum albumin colloids were injected subdermally the day before surgery (mean activity, 5.2 \u00b1 2.5 MBq). Scintigraphic imaging was performed after injection. After identification of the SN during surgery by a hand-held gamma probe, the SN was excised and sent for histologic examination. SN histology was compared with that of other axillary nodes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The SN detection rate was 86.3%; among 88 cases with an identified SN, 37 (42%) had axillary metastases; the SN was metastatic in 35 cases (sensitivity, 94.6%); in 51.3% of pN+ cases (19\/37) the SN was the only metastatic site. In two of the 53 negative SNs, SN histology did not match with that of the remaining axilla (negative predictive value, 96.2%; staging accuracy, 97.7%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results agree with those reported in the literature; however, except in clinical trials and experienced structures axillary lymph node dissection should not be abandoned when mandatory for prognostic purposes, considering that at present SN biopsy alone is not completely accurate for axillary staging, especially in the absence of an adequate learning period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089160008600409","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T12:37:07Z","timestamp":1523882227000},"page":"300-303","source":"Crossref","is-referenced-by-count":4,"title":["Sentinel Lymph Node and Breast Cancer Staging: Final Results of the Turin Multicenter Study"],"prefix":"10.1177","volume":"86","author":[{"given":"Paola Sorba","family":"Casalegno","sequence":"first","affiliation":[{"name":"Unit\u00e0 Operativa di Chirurgia Oncologica, Universit\u00e0 di Torino; Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Sandrucci","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Chirurgia Oncologica, Universit\u00e0 di Torino; Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilena","family":"Bell\u00f2","sequence":"additional","affiliation":[{"name":"Servizio di Medicina Nucleare, Universit\u00e0 di Torino; Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Durando","sequence":"additional","affiliation":[{"name":"Dipartimento di Ginecologia ed Ostetricia, I Clinica, Universit\u00e0 di Torino; Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saverio","family":"Danese","sequence":"additional","affiliation":[{"name":"Divisione A Ginecologia ed Ostetricia, A.O. OIRM-S. Anna, Turin; Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandra","family":"Silvestro","sequence":"additional","affiliation":[{"name":"Servizio di Medicina Nucleare A. O. OIRM-S. Anna, Turin; Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Pellerito","sequence":"additional","affiliation":[{"name":"Servizio di Medicina Nucleare, Ospedale Mauriziano Umberto I, Turin; Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ornella","family":"Testori","sequence":"additional","affiliation":[{"name":"Servizio di Medicina Nucleare, Ospedale Mauriziano Umberto I, Turin; Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Roagna","sequence":"additional","affiliation":[{"name":"Dipartimento di Ginecologia Oncologica, Universit\u00e0 d\u00ec Torino; Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizia","family":"Giai","sequence":"additional","affiliation":[{"name":"Dipartimento di Ginecologia Oncologica, Universit\u00e0 d\u00ec Torino; Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Giani","sequence":"additional","affiliation":[{"name":"I Chirurgia, Ospedale S. Giovanni Antica Sede, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Bussone","sequence":"additional","affiliation":[{"name":"I Chirurgia, Ospedale S. 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